Cargando…

Directed Evolution of Therapeutic Antibodies Targeting Glycosylation in Cancer

SIMPLE SUMMARY: We generated a platform for designing optimized functional therapeutic antibodies against cancer glycans. The target tumor-associated carbohydrate antigen is commonly expressed in colon and pancreatic cancers. We developed a system for selection of potent antibodies by yeast surface...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amon, Ron, Rosenfeld, Ronit, Perlmutter, Shahar, Grant, Oliver C., Yehuda, Sharon, Borenstein-Katz, Aliza, Alcalay, Ron, Marshanski, Tal, Yu, Hai, Diskin, Ron, Woods, Robert J., Chen, Xi, Padler-Karavani, Vered
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601599/ https://www.ncbi.nlm.nih.gov/pubmed/33007970 http://dx.doi.org/10.3390/cancers12102824

Ejemplares similares

Rational design of universal immunotherapy for TfR1-tropic arenaviruses
por: Cohen-Dvashi, Hadas, et al.
Publicado: (2020)

Glycosylated Biotherapeutics: Immunological Effects of N-Glycolylneuraminic Acid
por: Yehuda, Sharon, et al.
Publicado: (2020)

A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen
por: Amon, Ron, et al.
Publicado: (2018)

Evolution of sialic acids: Implications in xenotransplant biology
por: Paul, Anu, et al.
Publicado: (2018)

Editorial: Human Antibodies Against the Dietary Non-human Neu5Gc-Carrying Glycans in Normal and Pathologic States
por: Soulillou, Jean-Paul, et al.
Publicado: (2020)

Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy
por: Amon, Ron, et al.
Publicado: (2017)

Characterization of antibody-antigen interactions using biolayer interferometry
por: Noy-Porat, Tal, et al.
Publicado: (2021)

Xenotransplantation: The Way beyond and Ahead toward Clinical Application
por: Iop, Laura, et al.
Publicado: (2018)

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice
por: Noy-Porat, Tal, et al.
Publicado: (2021)

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation
por: Ng, Preston S. K., et al.
Publicado: (2019)

A Simple Method for Assessment of Human Anti-Neu5Gc Antibodies Applied to Kawasaki Disease
por: Padler-Karavani, Vered, et al.
Publicado: (2013)

Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates
por: Noy-Porat, Tal, et al.
Publicado: (2016)

Structural basis for matriglycan synthesis by the LARGE1 dual glycosyltransferase
por: Katz, Michael, et al.
Publicado: (2022)

ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences
por: Shanthamurthy, Chethan D., et al.
Publicado: (2018)

Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant Viruses
por: Levy, Yinon, et al.
Publicado: (2022)

Discovery of rare sulfated N-unsubstituted glucosamine based heparan sulfate analogs selectively activating chemokines
por: Jain, Prashant, et al.
Publicado: (2021)

Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces
por: Warszawski, Shira, et al.
Publicado: (2019)

Correction: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces
por: Warszawski, Shira, et al.
Publicado: (2020)

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid
por: Taylor, Rachel E., et al.
Publicado: (2010)

Generation of recombinant mAbs to vaccinia virus displaying high affinity and potent neutralization
por: Noy-Porat, Tal, et al.
Publicado: (2023)

Sensitive and Specific Detection of the Non-Human Sialic Acid N-Glycolylneuraminic Acid In Human Tissues and Biotherapeutic Products
por: Diaz, Sandra L., et al.
Publicado: (2009)

Rapid characterization of secreted recombinant proteins by native mass spectrometry
por: Ben-Nissan, Gili, et al.
Publicado: (2018)

Novel Phage Display-Derived Anti-Abrin Antibodies Confer Post-Exposure Protection against Abrin Intoxication
por: Mechaly, Adva, et al.
Publicado: (2018)

Wake-up call for HPPP – health promotion, prevention, and preparedness
por: Lev, Vered, et al.
Publicado: (2023)

Neutralizing Monoclonal Anti-SARS-CoV-2 Antibodies Isolated from Immunized Rabbits Define Novel Vulnerable Spike-Protein Epitope
por: Makdasi, Efi, et al.
Publicado: (2021)

Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice
por: Bar-On, Liat, et al.
Publicado: (2022)

The Paper Mache Bra: A Postsurgical Breast Taping Technique
por: Borenstein, Amiram, et al.
Publicado: (2019)

Centaur antibodies: Engineered chimeric equine-human recombinant antibodies
por: Rosenfeld, Ronit, et al.
Publicado: (2022)

Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity
por: Diskin, Ron, et al.
Publicado: (2010)

Intestinal Gel-Forming Mucins Polymerize by Disulfide-Mediated Dimerization of D3 Domains
por: Javitt, Gabriel, et al.
Publicado: (2019)

Fc-Independent Protection from SARS-CoV-2 Infection by Recombinant Human Monoclonal Antibodies
por: Noy-Porat, Tal, et al.
Publicado: (2021)

Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to cancer: French NutriNet-Santé study
por: Bashir, Salam, et al.
Publicado: (2020)

Spike vs nucleocapsid SARS-CoV-2 antigen detection: application in nasopharyngeal swab specimens
por: Barlev-Gross, Moria, et al.
Publicado: (2021)

Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses
por: Israeli, Hadar, et al.
Publicado: (2017)

Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk
por: Samraj, Annie N., et al.
Publicado: (2018)

Multifunctional degradable electronic scaffolds for cardiac tissue engineering
por: Feiner, Ron, et al.
Publicado: (2018)

Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
por: Rosenfeld, Ronit, et al.
Publicado: (2021)

Transferrin mutations at the glycosylation site complicate diagnosis of congenital disorders of glycosylation type I
por: Guillard, Mailys, et al.
Publicado: (2011)

Mannosidase activity of EDEM1 and EDEM2 depends on an unfolded state of their glycoprotein substrates
por: Shenkman, Marina, et al.
Publicado: (2018)

Incongruity between Affinity Patterns Based on Mandibular and Lower Dental Dimensions following the Transition to Agriculture in the Near East, Anatolia and Europe
por: Pinhasi, Ron, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_78u7n3he9ulq7441ijf5a886mf