Cargando…
Human Serum Albumin Binds Native Insulin and Aggregable Insulin Fragments and Inhibits Their Aggregation
The purpose of this study was to investigate whether Human Serum Albumin (HSA) can bind native human insulin and its A13–A19 and B12–B17 fragments, which are responsible for the aggregation of the whole hormone. To label the hormone and both hot spots, so that their binding positions within the HSA...
Autores principales: | Wasko, Joanna, Wolszczak, Marian, Kaminski, Zbigniew J., Steblecka, Malgorzata, Kolesinska, Beata |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601681/ https://www.ncbi.nlm.nih.gov/pubmed/32992893 http://dx.doi.org/10.3390/biom10101366 |
Ejemplares similares
-
Search for New Aggregable Fragments of Human Insulin
por: Swiontek, Monika, et al.
Publicado: (2019) -
Insulin Hot-Spot Analogs Formed with N-Methylated Amino Acid Residues Inhibit Aggregation of Native Hormone
por: Swiontek, Monika, et al.
Publicado: (2019) -
Spontaneous and Ionizing Radiation-Induced Aggregation of Human Serum Albumin: Dityrosine as a Fluorescent Probe
por: Radomska, Karolina, et al.
Publicado: (2022) -
Search for Fibrous Aggregates Potentially Useful in Regenerative Medicine Formed under Physiological Conditions by Self-Assembling Short Peptides Containing Two Identical Aromatic Amino Acid Residues
por: Fraczyk, Justyna, et al.
Publicado: (2018) -
Human Serum Albumin Aggregation/Fibrillation and its Abilities to Drugs Binding
por: Maciążek-Jurczyk, Małgorzata, et al.
Publicado: (2020)