Cargando…
Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial
Background: Patients with HIV (PWH) develop geriatric comorbidities, including functional and cognitive decline at a younger age. However, contributing mechanisms are unclear and interventions are lacking. We hypothesized that deficiency of the antioxidant protein glutathione (GSH) contributes to mu...
Autores principales: | Kumar, Premranjan, Liu, Chun, Suliburk, James W., Minard, Charles G., Muthupillai, Raja, Chacko, Shaji, Hsu, Jean W., Jahoor, Farook, Sekhar, Rajagopal V. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601820/ https://www.ncbi.nlm.nih.gov/pubmed/33007928 http://dx.doi.org/10.3390/biomedicines8100390 |
Ejemplares similares
-
Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial
por: Kumar, Premranjan, et al.
Publicado: (2021) -
Reversing cognitive-decline in older adults in an open-label clinical trial: novel mechanisms and the role of GlyNAC
por: Liu, Chun, et al.
Publicado: (2020) -
GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage
por: Kumar, Premranjan, et al.
Publicado: (2022) -
Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) Supplementation
por: Kumar, Premranjan, et al.
Publicado: (2021) -
SUPPLEMENTING GLYNAC IN AGING IMPROVES GLUTATHIONE, MITOCHONDRIA, AND AGING HALLMARKS: A RANDOMIZED CLINICAL TRIAL
por: Sekhar, Rajagopal, et al.
Publicado: (2022)