Genetic Variation Putatively Associated with Mycobacterium tuberculosis Resistance to Perchlozone, a New Thiosemicarbazone: Clues from Whole Genome Sequencing and Implications for Treatment of Multidrug-Resistant Tuberculosis

Perchlozone ([PCZ] 4-thioureido-iminomethylpyridinium perchlorate) is a new thiosemicarbazone approved for the treatment of multidrug-resistant tuberculosis (MDR-TB) in Russia and some other countries. The ethA and hadABC mutations may confer PCZ resistance. At the same time, ethA mutations are know...

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Detalles Bibliográficos
Autores principales: Mokrousov, Igor, Vyazovaya, Anna, Akhmedova, Gulnora, Solovieva, Natalia, Turkin, Eugeni, Zhuravlev, Viacheslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601826/
https://www.ncbi.nlm.nih.gov/pubmed/33022959
http://dx.doi.org/10.3390/antibiotics9100669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601826/
https://www.ncbi.nlm.nih.gov/pubmed/33022959
http://dx.doi.org/10.3390/antibiotics9100669

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