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Novel Nanocomposites Based on Bacterial Polyester/LDH-SDS Clay for Stem Cells Delivery in Modern Wound Healing Management
Nanocomposite materials based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) and modified mineral clay layered double hydroxides (LDH-SDS) were explored as novel nanostructured materials for potential tissue engineering applications. The mineral clay inorganic phase was modified with an ani...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601887/ https://www.ncbi.nlm.nih.gov/pubmed/33050441 http://dx.doi.org/10.3390/ma13204488 |
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author | Vasile, Eugeniu Radu, Ionut-Cristian Galateanu, Bianca Rapa, Maria Hudita, Ariana Jianu, Dana Stanescu, Paul-Octavian Cioflan, Horia Zaharia, Catalin |
author_facet | Vasile, Eugeniu Radu, Ionut-Cristian Galateanu, Bianca Rapa, Maria Hudita, Ariana Jianu, Dana Stanescu, Paul-Octavian Cioflan, Horia Zaharia, Catalin |
author_sort | Vasile, Eugeniu |
collection | PubMed |
description | Nanocomposite materials based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) and modified mineral clay layered double hydroxides (LDH-SDS) were explored as novel nanostructured materials for potential tissue engineering applications. The mineral clay inorganic phase was modified with an anionic long-chain structure of carbon atoms, such as sodium dodecyl sulfate, in order to increase the compatibility between the two phases. The melt intercalation method used for nanocomposite fabrication ensures a good dispersion of the modified LDH-SDS within the polymer matrix without using a toxic solvent (chloroform). The nanocomposites were found to have an intercalated/exfoliated structure with an enhanced Young modulus and increased stiffness. This could allow them to be considered for autologous stem cells dressings in the view of efficient wound healing applications. |
format | Online Article Text |
id | pubmed-7601887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76018872020-11-01 Novel Nanocomposites Based on Bacterial Polyester/LDH-SDS Clay for Stem Cells Delivery in Modern Wound Healing Management Vasile, Eugeniu Radu, Ionut-Cristian Galateanu, Bianca Rapa, Maria Hudita, Ariana Jianu, Dana Stanescu, Paul-Octavian Cioflan, Horia Zaharia, Catalin Materials (Basel) Article Nanocomposite materials based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) and modified mineral clay layered double hydroxides (LDH-SDS) were explored as novel nanostructured materials for potential tissue engineering applications. The mineral clay inorganic phase was modified with an anionic long-chain structure of carbon atoms, such as sodium dodecyl sulfate, in order to increase the compatibility between the two phases. The melt intercalation method used for nanocomposite fabrication ensures a good dispersion of the modified LDH-SDS within the polymer matrix without using a toxic solvent (chloroform). The nanocomposites were found to have an intercalated/exfoliated structure with an enhanced Young modulus and increased stiffness. This could allow them to be considered for autologous stem cells dressings in the view of efficient wound healing applications. MDPI 2020-10-10 /pmc/articles/PMC7601887/ /pubmed/33050441 http://dx.doi.org/10.3390/ma13204488 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vasile, Eugeniu Radu, Ionut-Cristian Galateanu, Bianca Rapa, Maria Hudita, Ariana Jianu, Dana Stanescu, Paul-Octavian Cioflan, Horia Zaharia, Catalin Novel Nanocomposites Based on Bacterial Polyester/LDH-SDS Clay for Stem Cells Delivery in Modern Wound Healing Management |
title | Novel Nanocomposites Based on Bacterial Polyester/LDH-SDS Clay for Stem Cells Delivery in Modern Wound Healing Management |
title_full | Novel Nanocomposites Based on Bacterial Polyester/LDH-SDS Clay for Stem Cells Delivery in Modern Wound Healing Management |
title_fullStr | Novel Nanocomposites Based on Bacterial Polyester/LDH-SDS Clay for Stem Cells Delivery in Modern Wound Healing Management |
title_full_unstemmed | Novel Nanocomposites Based on Bacterial Polyester/LDH-SDS Clay for Stem Cells Delivery in Modern Wound Healing Management |
title_short | Novel Nanocomposites Based on Bacterial Polyester/LDH-SDS Clay for Stem Cells Delivery in Modern Wound Healing Management |
title_sort | novel nanocomposites based on bacterial polyester/ldh-sds clay for stem cells delivery in modern wound healing management |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601887/ https://www.ncbi.nlm.nih.gov/pubmed/33050441 http://dx.doi.org/10.3390/ma13204488 |
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