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Tear Film Osmolarity Measurement in Japanese Dry Eye Patients Using a Handheld Osmolarity System

We studied the efficacy and safety of a handheld osmolarity measurement system (I-PEN) in Japanese patients with dry eye disease (DED) and non-DED subjects. In this prospective, multicenter study, tear osmolarity was examined using the I-PEN in a total of 122 eyes divided into DED (n = 71) and non-D...

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Autores principales: Shimazaki, Jun, Sakata, Miki, Den, Seika, Iwasaki, Miki, Toda, Ikuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601915/
https://www.ncbi.nlm.nih.gov/pubmed/33028019
http://dx.doi.org/10.3390/diagnostics10100789
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author Shimazaki, Jun
Sakata, Miki
Den, Seika
Iwasaki, Miki
Toda, Ikuko
author_facet Shimazaki, Jun
Sakata, Miki
Den, Seika
Iwasaki, Miki
Toda, Ikuko
author_sort Shimazaki, Jun
collection PubMed
description We studied the efficacy and safety of a handheld osmolarity measurement system (I-PEN) in Japanese patients with dry eye disease (DED) and non-DED subjects. In this prospective, multicenter study, tear osmolarity was examined using the I-PEN in a total of 122 eyes divided into DED (n = 71) and non-DED (n = 51) groups. Subjective symptoms were assessed using the Dry Eye-Related Quality-of-Life Score (DEQS) questionnaire. Ocular surface condition was evaluated in terms of fluorescein tear breakup time (FBUT) and tear breakup pattern (TBUP), and by fluorescein staining and Schirmer’s test. The I-PEN measurements were performed safely in the majority of cases. There was no statistically significant difference in mean tear film osmolarity between the DED and non-DED groups (294.76 ± 16.39 vs. 297.76 ± 16.72 mOsms/L, respectively, p = 0.32). No significant correlations were observed between osmolarity values and DEQS score, FBUT, or the Schirmer score. Osmolarity did not differ among TBUP subgroups. This prospective clinical study found no correlations between the tear film osmolarity values obtained with the I-PEN system and any subjective or objective parameters of DED. Further studies are required to determine the utility of the I-PEN system in other settings.
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spelling pubmed-76019152020-11-01 Tear Film Osmolarity Measurement in Japanese Dry Eye Patients Using a Handheld Osmolarity System Shimazaki, Jun Sakata, Miki Den, Seika Iwasaki, Miki Toda, Ikuko Diagnostics (Basel) Article We studied the efficacy and safety of a handheld osmolarity measurement system (I-PEN) in Japanese patients with dry eye disease (DED) and non-DED subjects. In this prospective, multicenter study, tear osmolarity was examined using the I-PEN in a total of 122 eyes divided into DED (n = 71) and non-DED (n = 51) groups. Subjective symptoms were assessed using the Dry Eye-Related Quality-of-Life Score (DEQS) questionnaire. Ocular surface condition was evaluated in terms of fluorescein tear breakup time (FBUT) and tear breakup pattern (TBUP), and by fluorescein staining and Schirmer’s test. The I-PEN measurements were performed safely in the majority of cases. There was no statistically significant difference in mean tear film osmolarity between the DED and non-DED groups (294.76 ± 16.39 vs. 297.76 ± 16.72 mOsms/L, respectively, p = 0.32). No significant correlations were observed between osmolarity values and DEQS score, FBUT, or the Schirmer score. Osmolarity did not differ among TBUP subgroups. This prospective clinical study found no correlations between the tear film osmolarity values obtained with the I-PEN system and any subjective or objective parameters of DED. Further studies are required to determine the utility of the I-PEN system in other settings. MDPI 2020-10-05 /pmc/articles/PMC7601915/ /pubmed/33028019 http://dx.doi.org/10.3390/diagnostics10100789 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shimazaki, Jun
Sakata, Miki
Den, Seika
Iwasaki, Miki
Toda, Ikuko
Tear Film Osmolarity Measurement in Japanese Dry Eye Patients Using a Handheld Osmolarity System
title Tear Film Osmolarity Measurement in Japanese Dry Eye Patients Using a Handheld Osmolarity System
title_full Tear Film Osmolarity Measurement in Japanese Dry Eye Patients Using a Handheld Osmolarity System
title_fullStr Tear Film Osmolarity Measurement in Japanese Dry Eye Patients Using a Handheld Osmolarity System
title_full_unstemmed Tear Film Osmolarity Measurement in Japanese Dry Eye Patients Using a Handheld Osmolarity System
title_short Tear Film Osmolarity Measurement in Japanese Dry Eye Patients Using a Handheld Osmolarity System
title_sort tear film osmolarity measurement in japanese dry eye patients using a handheld osmolarity system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601915/
https://www.ncbi.nlm.nih.gov/pubmed/33028019
http://dx.doi.org/10.3390/diagnostics10100789
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