Detargeting Lentiviral-Mediated CFTR Expression in Airway Basal Cells Using miR-106b

Lentiviral-mediated integration of a CFTR transgene cassette into airway basal cells is a strategy being considered for cystic fibrosis (CF) cell-based therapies. However, CFTR expression is highly regulated in differentiated airway cell types and a subset of intermediate basal cells destined to dif...

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Detalles Bibliográficos
Autores principales: Choi, Soon H., Reeves, Rosie E., Romano Ibarra, Guillermo S., Lynch, Thomas J., Shahin, Weam S., Feng, Zehua, Gasser, Grace N., Winter, Michael C., Evans, T. Idil Apak, Liu, Xiaoming, Luo, Meihui, Zhang, Yulong, Stoltz, David A., Devor, Eric J., Yan, Ziying, Engelhardt, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601932/
https://www.ncbi.nlm.nih.gov/pubmed/33036232
http://dx.doi.org/10.3390/genes11101169

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