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Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life

Piglets are susceptible to infections in early life and around weaning due to rapid environmental and dietary changes. A compelling target to improve pig health in early life is diet, as it constitutes a pivotal determinant of gut microbial colonization and maturation of the host’s immune system. In...

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Autores principales: de Vries, Hugo, Geervliet, Mirelle, Jansen, Christine A., Rutten, Victor P. M. G., van Hees, Hubèrt, Groothuis, Natalie, Wells, Jerry M., Savelkoul, Huub F. J., Tijhaar, Edwin, Smidt, Hauke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601942/
https://www.ncbi.nlm.nih.gov/pubmed/33066115
http://dx.doi.org/10.3390/microorganisms8101573
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author de Vries, Hugo
Geervliet, Mirelle
Jansen, Christine A.
Rutten, Victor P. M. G.
van Hees, Hubèrt
Groothuis, Natalie
Wells, Jerry M.
Savelkoul, Huub F. J.
Tijhaar, Edwin
Smidt, Hauke
author_facet de Vries, Hugo
Geervliet, Mirelle
Jansen, Christine A.
Rutten, Victor P. M. G.
van Hees, Hubèrt
Groothuis, Natalie
Wells, Jerry M.
Savelkoul, Huub F. J.
Tijhaar, Edwin
Smidt, Hauke
author_sort de Vries, Hugo
collection PubMed
description Piglets are susceptible to infections in early life and around weaning due to rapid environmental and dietary changes. A compelling target to improve pig health in early life is diet, as it constitutes a pivotal determinant of gut microbial colonization and maturation of the host’s immune system. In the present study, we investigated how supplementation of yeast-derived β-glucans affects the gut microbiota and immune function pre- and post-weaning, and how these complex systems develop over time. From day two after birth until two weeks after weaning, piglets received yeast-derived β-glucans or a control treatment orally and were subsequently vaccinated against Salmonella Typhimurium. Faeces, digesta, blood, and tissue samples were collected to study gut microbiota composition and immune function. Overall, yeast-derived β-glucans did not affect the vaccination response, and only modest effects on faecal microbiota composition and immune parameters were observed, primarily before weaning. This study demonstrates that the pre-weaning period offers a ‘window of opportunity’ to alter the gut microbiota and immune system through diet. However, the observed changes were modest, and any long-lasting effects of yeast-derived β-glucans remain to be elucidated.
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spelling pubmed-76019422020-11-01 Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life de Vries, Hugo Geervliet, Mirelle Jansen, Christine A. Rutten, Victor P. M. G. van Hees, Hubèrt Groothuis, Natalie Wells, Jerry M. Savelkoul, Huub F. J. Tijhaar, Edwin Smidt, Hauke Microorganisms Article Piglets are susceptible to infections in early life and around weaning due to rapid environmental and dietary changes. A compelling target to improve pig health in early life is diet, as it constitutes a pivotal determinant of gut microbial colonization and maturation of the host’s immune system. In the present study, we investigated how supplementation of yeast-derived β-glucans affects the gut microbiota and immune function pre- and post-weaning, and how these complex systems develop over time. From day two after birth until two weeks after weaning, piglets received yeast-derived β-glucans or a control treatment orally and were subsequently vaccinated against Salmonella Typhimurium. Faeces, digesta, blood, and tissue samples were collected to study gut microbiota composition and immune function. Overall, yeast-derived β-glucans did not affect the vaccination response, and only modest effects on faecal microbiota composition and immune parameters were observed, primarily before weaning. This study demonstrates that the pre-weaning period offers a ‘window of opportunity’ to alter the gut microbiota and immune system through diet. However, the observed changes were modest, and any long-lasting effects of yeast-derived β-glucans remain to be elucidated. MDPI 2020-10-13 /pmc/articles/PMC7601942/ /pubmed/33066115 http://dx.doi.org/10.3390/microorganisms8101573 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Vries, Hugo
Geervliet, Mirelle
Jansen, Christine A.
Rutten, Victor P. M. G.
van Hees, Hubèrt
Groothuis, Natalie
Wells, Jerry M.
Savelkoul, Huub F. J.
Tijhaar, Edwin
Smidt, Hauke
Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life
title Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life
title_full Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life
title_fullStr Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life
title_full_unstemmed Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life
title_short Impact of Yeast-Derived β-Glucans on the Porcine Gut Microbiota and Immune System in Early Life
title_sort impact of yeast-derived β-glucans on the porcine gut microbiota and immune system in early life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601942/
https://www.ncbi.nlm.nih.gov/pubmed/33066115
http://dx.doi.org/10.3390/microorganisms8101573
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