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Regenerative Wound Dressings for Skin Cancer

SIMPLE SUMMARY: As the currently and commonly applied treatment strategies for skin cancer are highly invasive and possibly disfiguring, new approaches should focus on developing wound dressings that could promote both tumor eradication and skin regeneration. In this context, we aim to provide a com...

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Autores principales: Pavel, Teodor Iulian, Chircov, Cristina, Rădulescu, Marius, Grumezescu, Alexandru Mihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601961/
https://www.ncbi.nlm.nih.gov/pubmed/33066077
http://dx.doi.org/10.3390/cancers12102954
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author Pavel, Teodor Iulian
Chircov, Cristina
Rădulescu, Marius
Grumezescu, Alexandru Mihai
author_facet Pavel, Teodor Iulian
Chircov, Cristina
Rădulescu, Marius
Grumezescu, Alexandru Mihai
author_sort Pavel, Teodor Iulian
collection PubMed
description SIMPLE SUMMARY: As the currently and commonly applied treatment strategies for skin cancer are highly invasive and possibly disfiguring, new approaches should focus on developing wound dressings that could promote both tumor eradication and skin regeneration. In this context, we aim to provide a complete overview on the limitations of currently available topical field treatments and to emphasize on the potential of natural biocompounds with anti-cancer and anti-microbial effects that could be introduced into wound dressings consisting of biopolymers with regenerative capacities. This paper could represent the first step towards the scientific advancement of regenerative wound dressings for skin cancer therapy. ABSTRACT: Skin cancer is considered the most prevalent cancer type globally, with a continuously increasing prevalence and mortality growth rate. Additionally, the high risk of recurrence makes skin cancer treatment among the most expensive of all cancers, with average costs estimated to double within 5 years. Although tumor excision is the most effective approach among the available strategies, surgical interventions could be disfiguring, requiring additional skin grafts for covering the defects. In this context, post-surgery management should involve the application of wound dressings for promoting skin regeneration and preventing tumor recurrence and microbial infections, which still represents a considerable clinical challenge. Therefore, this paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described.
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spelling pubmed-76019612020-11-01 Regenerative Wound Dressings for Skin Cancer Pavel, Teodor Iulian Chircov, Cristina Rădulescu, Marius Grumezescu, Alexandru Mihai Cancers (Basel) Review SIMPLE SUMMARY: As the currently and commonly applied treatment strategies for skin cancer are highly invasive and possibly disfiguring, new approaches should focus on developing wound dressings that could promote both tumor eradication and skin regeneration. In this context, we aim to provide a complete overview on the limitations of currently available topical field treatments and to emphasize on the potential of natural biocompounds with anti-cancer and anti-microbial effects that could be introduced into wound dressings consisting of biopolymers with regenerative capacities. This paper could represent the first step towards the scientific advancement of regenerative wound dressings for skin cancer therapy. ABSTRACT: Skin cancer is considered the most prevalent cancer type globally, with a continuously increasing prevalence and mortality growth rate. Additionally, the high risk of recurrence makes skin cancer treatment among the most expensive of all cancers, with average costs estimated to double within 5 years. Although tumor excision is the most effective approach among the available strategies, surgical interventions could be disfiguring, requiring additional skin grafts for covering the defects. In this context, post-surgery management should involve the application of wound dressings for promoting skin regeneration and preventing tumor recurrence and microbial infections, which still represents a considerable clinical challenge. Therefore, this paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described. MDPI 2020-10-13 /pmc/articles/PMC7601961/ /pubmed/33066077 http://dx.doi.org/10.3390/cancers12102954 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pavel, Teodor Iulian
Chircov, Cristina
Rădulescu, Marius
Grumezescu, Alexandru Mihai
Regenerative Wound Dressings for Skin Cancer
title Regenerative Wound Dressings for Skin Cancer
title_full Regenerative Wound Dressings for Skin Cancer
title_fullStr Regenerative Wound Dressings for Skin Cancer
title_full_unstemmed Regenerative Wound Dressings for Skin Cancer
title_short Regenerative Wound Dressings for Skin Cancer
title_sort regenerative wound dressings for skin cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601961/
https://www.ncbi.nlm.nih.gov/pubmed/33066077
http://dx.doi.org/10.3390/cancers12102954
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