Cargando…
Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors
Aims and objectives: In order to evaluate the responses of hepatic lesions to treatment in terms of tissue stiffness and heterogeneity, this work investigated the robustness of 2D shear-wave elastography (2D SWE) stiffness measurements and texture analyses in vitro and in vivo in terms of repeatabil...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602000/ https://www.ncbi.nlm.nih.gov/pubmed/33066135 http://dx.doi.org/10.3390/diagnostics10100811 |
_version_ | 1783603567298347008 |
---|---|
author | Moalla, Salma Girot, Charly Franchi-Abella, Stéphanie Ammari, Samy Balleyguier, Corinne Lassau, Nathalie Pitre-Champagnat, Stéphanie |
author_facet | Moalla, Salma Girot, Charly Franchi-Abella, Stéphanie Ammari, Samy Balleyguier, Corinne Lassau, Nathalie Pitre-Champagnat, Stéphanie |
author_sort | Moalla, Salma |
collection | PubMed |
description | Aims and objectives: In order to evaluate the responses of hepatic lesions to treatment in terms of tissue stiffness and heterogeneity, this work investigated the robustness of 2D shear-wave elastography (2D SWE) stiffness measurements and texture analyses in vitro and in vivo in terms of repeatability and variability. Methods and materials: A multioperator (n = 5) study was performed with an ultrasonic elastography device on two sets of phantoms. For the first set of phantoms, 10 measurements for each of the eight inclusions were performed by each observer, whereas the second set of phantoms was used to evaluate the influence of depth on the stiffness measurements. Variability of the stiffness measurements was evaluated in vivo on 10 healthy livers, with 10 measurements for each hepatic segment. Texture analyses were performed in B-mode, obtaining elastography images for every hepatic segment. Results: Stiffness measurements were influenced by depth, particularly when exceeding 7 cm. In vivo measurements demonstrated that measurements of segments I, VII, and VIII were less reliable, mainly due to their deeper locations. The protocols used were more flexible in terms of acquisition setup and probe placement than those currently used with Fibroscan(®). For texture analysis on the B-mode images, 12 features showed low variability regardless of the evaluated hepatic segment. On elastogram, only two features showed low variability, but not in every segment. Conclusion: We demonstrated the robustness of two methodologies for the quantification of liver stiffness and heterogeneity. Further clinical studies should evaluate whether these techniques can assess tumor responses to treatment and, therefore, have the potential to be used as imaging biomarkers. |
format | Online Article Text |
id | pubmed-7602000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76020002020-11-01 Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors Moalla, Salma Girot, Charly Franchi-Abella, Stéphanie Ammari, Samy Balleyguier, Corinne Lassau, Nathalie Pitre-Champagnat, Stéphanie Diagnostics (Basel) Article Aims and objectives: In order to evaluate the responses of hepatic lesions to treatment in terms of tissue stiffness and heterogeneity, this work investigated the robustness of 2D shear-wave elastography (2D SWE) stiffness measurements and texture analyses in vitro and in vivo in terms of repeatability and variability. Methods and materials: A multioperator (n = 5) study was performed with an ultrasonic elastography device on two sets of phantoms. For the first set of phantoms, 10 measurements for each of the eight inclusions were performed by each observer, whereas the second set of phantoms was used to evaluate the influence of depth on the stiffness measurements. Variability of the stiffness measurements was evaluated in vivo on 10 healthy livers, with 10 measurements for each hepatic segment. Texture analyses were performed in B-mode, obtaining elastography images for every hepatic segment. Results: Stiffness measurements were influenced by depth, particularly when exceeding 7 cm. In vivo measurements demonstrated that measurements of segments I, VII, and VIII were less reliable, mainly due to their deeper locations. The protocols used were more flexible in terms of acquisition setup and probe placement than those currently used with Fibroscan(®). For texture analysis on the B-mode images, 12 features showed low variability regardless of the evaluated hepatic segment. On elastogram, only two features showed low variability, but not in every segment. Conclusion: We demonstrated the robustness of two methodologies for the quantification of liver stiffness and heterogeneity. Further clinical studies should evaluate whether these techniques can assess tumor responses to treatment and, therefore, have the potential to be used as imaging biomarkers. MDPI 2020-10-13 /pmc/articles/PMC7602000/ /pubmed/33066135 http://dx.doi.org/10.3390/diagnostics10100811 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moalla, Salma Girot, Charly Franchi-Abella, Stéphanie Ammari, Samy Balleyguier, Corinne Lassau, Nathalie Pitre-Champagnat, Stéphanie Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors |
title | Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors |
title_full | Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors |
title_fullStr | Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors |
title_full_unstemmed | Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors |
title_short | Methodological Study to Investigate the Potential of Ultrasound-Based Elastography and Texture as Biomarkers to Monitor Liver Tumors |
title_sort | methodological study to investigate the potential of ultrasound-based elastography and texture as biomarkers to monitor liver tumors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602000/ https://www.ncbi.nlm.nih.gov/pubmed/33066135 http://dx.doi.org/10.3390/diagnostics10100811 |
work_keys_str_mv | AT moallasalma methodologicalstudytoinvestigatethepotentialofultrasoundbasedelastographyandtextureasbiomarkerstomonitorlivertumors AT girotcharly methodologicalstudytoinvestigatethepotentialofultrasoundbasedelastographyandtextureasbiomarkerstomonitorlivertumors AT franchiabellastephanie methodologicalstudytoinvestigatethepotentialofultrasoundbasedelastographyandtextureasbiomarkerstomonitorlivertumors AT ammarisamy methodologicalstudytoinvestigatethepotentialofultrasoundbasedelastographyandtextureasbiomarkerstomonitorlivertumors AT balleyguiercorinne methodologicalstudytoinvestigatethepotentialofultrasoundbasedelastographyandtextureasbiomarkerstomonitorlivertumors AT lassaunathalie methodologicalstudytoinvestigatethepotentialofultrasoundbasedelastographyandtextureasbiomarkerstomonitorlivertumors AT pitrechampagnatstephanie methodologicalstudytoinvestigatethepotentialofultrasoundbasedelastographyandtextureasbiomarkerstomonitorlivertumors |