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Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects

Knowledge regarding the involvement of sweetness perception on energy intake is scarce. Here, the impact of glucose and sucrose sweetness, beyond their caloric load, on subsequent food intake and biomarkers of satiation was evaluated by co-administration of the sweet taste receptor inhibitor lactiso...

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Autores principales: Schweiger, Kerstin, Grüneis, Verena, Treml, Julia, Galassi, Claudia, Karl, Corinna M., Ley, Jakob P., Krammer, Gerhard E., Lieder, Barbara, Somoza, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602135/
https://www.ncbi.nlm.nih.gov/pubmed/33066498
http://dx.doi.org/10.3390/nu12103133
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author Schweiger, Kerstin
Grüneis, Verena
Treml, Julia
Galassi, Claudia
Karl, Corinna M.
Ley, Jakob P.
Krammer, Gerhard E.
Lieder, Barbara
Somoza, Veronika
author_facet Schweiger, Kerstin
Grüneis, Verena
Treml, Julia
Galassi, Claudia
Karl, Corinna M.
Ley, Jakob P.
Krammer, Gerhard E.
Lieder, Barbara
Somoza, Veronika
author_sort Schweiger, Kerstin
collection PubMed
description Knowledge regarding the involvement of sweetness perception on energy intake is scarce. Here, the impact of glucose and sucrose sweetness, beyond their caloric load, on subsequent food intake and biomarkers of satiation was evaluated by co-administration of the sweet taste receptor inhibitor lactisole. A total of 27 healthy, male subjects received solutions of either 10% glucose w/o 60 ppm lactisole or 10% sucrose w/o 60 ppm lactisole. Subsequent food intake from a standardized breakfast was evaluated 2 h after receiving the respective test solution. Changes in postprandial plasma concentrations of cholecystokinin, ghrelin, and serotonin were determined over a period of 120 min, as was the body temperature. Administration of lactisole to the sucrose solution increased the energy intake from the subsequent standardized breakfast by 12.9 ± 5.8% (p = 0.04), led to a decreased Δ AUC of the body core temperature by 46 ± 20% (p = 0.01), and time-dependently reduced Δ serotonin plasma concentrations (−16.9 ± 6.06 ng/mL vs. −0.56 ± 3.7 ng/mL after sucrose administration, p = 0.03). The present study shows that lactisole increases energy intake and decreases plasma serotonin concentrations as well as body core temperature induced by sucrose, but not glucose. This finding may be associated with the different binding affinities of sucrose and glucose to the sweet taste receptor.
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spelling pubmed-76021352020-11-01 Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects Schweiger, Kerstin Grüneis, Verena Treml, Julia Galassi, Claudia Karl, Corinna M. Ley, Jakob P. Krammer, Gerhard E. Lieder, Barbara Somoza, Veronika Nutrients Article Knowledge regarding the involvement of sweetness perception on energy intake is scarce. Here, the impact of glucose and sucrose sweetness, beyond their caloric load, on subsequent food intake and biomarkers of satiation was evaluated by co-administration of the sweet taste receptor inhibitor lactisole. A total of 27 healthy, male subjects received solutions of either 10% glucose w/o 60 ppm lactisole or 10% sucrose w/o 60 ppm lactisole. Subsequent food intake from a standardized breakfast was evaluated 2 h after receiving the respective test solution. Changes in postprandial plasma concentrations of cholecystokinin, ghrelin, and serotonin were determined over a period of 120 min, as was the body temperature. Administration of lactisole to the sucrose solution increased the energy intake from the subsequent standardized breakfast by 12.9 ± 5.8% (p = 0.04), led to a decreased Δ AUC of the body core temperature by 46 ± 20% (p = 0.01), and time-dependently reduced Δ serotonin plasma concentrations (−16.9 ± 6.06 ng/mL vs. −0.56 ± 3.7 ng/mL after sucrose administration, p = 0.03). The present study shows that lactisole increases energy intake and decreases plasma serotonin concentrations as well as body core temperature induced by sucrose, but not glucose. This finding may be associated with the different binding affinities of sucrose and glucose to the sweet taste receptor. MDPI 2020-10-14 /pmc/articles/PMC7602135/ /pubmed/33066498 http://dx.doi.org/10.3390/nu12103133 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schweiger, Kerstin
Grüneis, Verena
Treml, Julia
Galassi, Claudia
Karl, Corinna M.
Ley, Jakob P.
Krammer, Gerhard E.
Lieder, Barbara
Somoza, Veronika
Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects
title Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects
title_full Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects
title_fullStr Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects
title_full_unstemmed Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects
title_short Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects
title_sort sweet taste antagonist lactisole administered in combination with sucrose, but not glucose, increases energy intake and decreases peripheral serotonin in male subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602135/
https://www.ncbi.nlm.nih.gov/pubmed/33066498
http://dx.doi.org/10.3390/nu12103133
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