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Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia

With regard to differences in the clinical symptoms of preeclampsia (PE), the degree of endothelial dysfunction may differ between early and late-onset preeclampsia (EOP and LOP). The authors of this study examined it by assessing the endothelial injury level in women with EOP (20 patients) and LOP...

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Autores principales: Kornacki, Jakub, Wirstlein, Przemysław, Wender-Ozegowska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602169/
https://www.ncbi.nlm.nih.gov/pubmed/33066445
http://dx.doi.org/10.3390/life10100239
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author Kornacki, Jakub
Wirstlein, Przemysław
Wender-Ozegowska, Ewa
author_facet Kornacki, Jakub
Wirstlein, Przemysław
Wender-Ozegowska, Ewa
author_sort Kornacki, Jakub
collection PubMed
description With regard to differences in the clinical symptoms of preeclampsia (PE), the degree of endothelial dysfunction may differ between early and late-onset preeclampsia (EOP and LOP). The authors of this study examined it by assessing the endothelial injury level in women with EOP (20 patients) and LOP (20 patients) and in normotensive pregnant women (20 patients) in their late second and third trimesters of pregnancy, using the two markers—the serum concentration of hyaluronan (HA) and the serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1). The serum concentrations of HA and sVCAM-1 did not differ significantly between the EOP and LOP patients. However, these were statistically higher than that of the control group participants (p < 0.05; p < 0.001). A significant correlation between the levels of HA and sVCAM-1 was found both in the entire group of patients with preeclampsia (p = 0.0277) and in women with late-onset disease (p = 0.0364), but not in the patients with early-onset preeclampsia (p = 0.331). The obtained results indicated a comparable level of endothelial injury in the two types of PE. The presence of a similar degree of endothelial injury in patients with EOP and LOP should create awareness among all clinicians about the possible fatal complications in both groups of patients with PE.
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spelling pubmed-76021692020-11-01 Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia Kornacki, Jakub Wirstlein, Przemysław Wender-Ozegowska, Ewa Life (Basel) Article With regard to differences in the clinical symptoms of preeclampsia (PE), the degree of endothelial dysfunction may differ between early and late-onset preeclampsia (EOP and LOP). The authors of this study examined it by assessing the endothelial injury level in women with EOP (20 patients) and LOP (20 patients) and in normotensive pregnant women (20 patients) in their late second and third trimesters of pregnancy, using the two markers—the serum concentration of hyaluronan (HA) and the serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1). The serum concentrations of HA and sVCAM-1 did not differ significantly between the EOP and LOP patients. However, these were statistically higher than that of the control group participants (p < 0.05; p < 0.001). A significant correlation between the levels of HA and sVCAM-1 was found both in the entire group of patients with preeclampsia (p = 0.0277) and in women with late-onset disease (p = 0.0364), but not in the patients with early-onset preeclampsia (p = 0.331). The obtained results indicated a comparable level of endothelial injury in the two types of PE. The presence of a similar degree of endothelial injury in patients with EOP and LOP should create awareness among all clinicians about the possible fatal complications in both groups of patients with PE. MDPI 2020-10-14 /pmc/articles/PMC7602169/ /pubmed/33066445 http://dx.doi.org/10.3390/life10100239 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kornacki, Jakub
Wirstlein, Przemysław
Wender-Ozegowska, Ewa
Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia
title Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia
title_full Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia
title_fullStr Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia
title_full_unstemmed Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia
title_short Markers of Endothelial Injury and Dysfunction in Early- and Late-Onset Preeclampsia
title_sort markers of endothelial injury and dysfunction in early- and late-onset preeclampsia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602169/
https://www.ncbi.nlm.nih.gov/pubmed/33066445
http://dx.doi.org/10.3390/life10100239
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