Therapeutic Potential of PI3K/AKT/mTOR Pathway in Gastrointestinal Stromal Tumors: Rationale and Progress

SIMPLE SUMMARY: Most gastrointestinal stromal tumors (GISTs) arise due to gain-of-function mutations of KIT and PDGFRA, encoding the receptor tyrosine kinase (RTK). The introduction of the RTK inhibitor imatinib has significantly improved the management of GISTs; however, drug resistance remains a c...

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Detalles Bibliográficos
Autores principales: Duan, Yi, Haybaeck, Johannes, Yang, Zhihui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602170/
https://www.ncbi.nlm.nih.gov/pubmed/33066449
http://dx.doi.org/10.3390/cancers12102972

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