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Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein

Background: One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on...

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Autores principales: Cordaro, Marika, Fusco, Roberta, D’Amico, Ramona, Siracusa, Rosalba, Peritore, Alessio Filippo, Gugliandolo, Enrico, Genovese, Tiziana, Crupi, Rosalia, Mandalari, Giuseppina, Cuzzocrea, Salvatore, Di Paola, Rosanna, Impellizzeri, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602264/
https://www.ncbi.nlm.nih.gov/pubmed/33066525
http://dx.doi.org/10.3390/antiox9100992
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author Cordaro, Marika
Fusco, Roberta
D’Amico, Ramona
Siracusa, Rosalba
Peritore, Alessio Filippo
Gugliandolo, Enrico
Genovese, Tiziana
Crupi, Rosalia
Mandalari, Giuseppina
Cuzzocrea, Salvatore
Di Paola, Rosanna
Impellizzeri, Daniela
author_facet Cordaro, Marika
Fusco, Roberta
D’Amico, Ramona
Siracusa, Rosalba
Peritore, Alessio Filippo
Gugliandolo, Enrico
Genovese, Tiziana
Crupi, Rosalia
Mandalari, Giuseppina
Cuzzocrea, Salvatore
Di Paola, Rosanna
Impellizzeri, Daniela
author_sort Cordaro, Marika
collection PubMed
description Background: One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on nuclear factor E2-related factor 2 (Nrf2) and nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 (NLRP3), has not been fully elucidated. Methods: To investigate the effect of cashew (Anacardium occidentale L.) nuts on pancreatic and lung injury induced by cerulein injection, cerulein (50 μg/kg) was administered to CD1 mice for 10 h. Oral treatment with cashew nuts at a dose of 100 mg/kg was given 30 min and 2 h after the first cerulein injection. One hour after the final cerulein injection, mice were euthanized and blood, lung and pancreatic tissue samples were collected. Results: Cashew nuts were able to (1) reduce histological damage; (2) mitigate the induction of mast cell degranulation as well as the activity of myeloperoxidase and malondialdehyde; (3) decrease the activity levels of amylase and lipase as well as the levels of pro-inflammatory cytokines; and (4) enhance the activation of the Nrf2 pathway and suppress the activation of the NLRP3 pathway in response to cerulein in both pancreas and lung. Conclusions: Cashew nuts could have a beneficial effect not only on pancreatitis but also on lung injury induced by cerulein.
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spelling pubmed-76022642020-11-01 Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein Cordaro, Marika Fusco, Roberta D’Amico, Ramona Siracusa, Rosalba Peritore, Alessio Filippo Gugliandolo, Enrico Genovese, Tiziana Crupi, Rosalia Mandalari, Giuseppina Cuzzocrea, Salvatore Di Paola, Rosanna Impellizzeri, Daniela Antioxidants (Basel) Article Background: One of the most common co-morbidities, that often leads to death, associated with acute pancreatitis (AP) is represented by acute lung injury (ALI). While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on nuclear factor E2-related factor 2 (Nrf2) and nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 (NLRP3), has not been fully elucidated. Methods: To investigate the effect of cashew (Anacardium occidentale L.) nuts on pancreatic and lung injury induced by cerulein injection, cerulein (50 μg/kg) was administered to CD1 mice for 10 h. Oral treatment with cashew nuts at a dose of 100 mg/kg was given 30 min and 2 h after the first cerulein injection. One hour after the final cerulein injection, mice were euthanized and blood, lung and pancreatic tissue samples were collected. Results: Cashew nuts were able to (1) reduce histological damage; (2) mitigate the induction of mast cell degranulation as well as the activity of myeloperoxidase and malondialdehyde; (3) decrease the activity levels of amylase and lipase as well as the levels of pro-inflammatory cytokines; and (4) enhance the activation of the Nrf2 pathway and suppress the activation of the NLRP3 pathway in response to cerulein in both pancreas and lung. Conclusions: Cashew nuts could have a beneficial effect not only on pancreatitis but also on lung injury induced by cerulein. MDPI 2020-10-14 /pmc/articles/PMC7602264/ /pubmed/33066525 http://dx.doi.org/10.3390/antiox9100992 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cordaro, Marika
Fusco, Roberta
D’Amico, Ramona
Siracusa, Rosalba
Peritore, Alessio Filippo
Gugliandolo, Enrico
Genovese, Tiziana
Crupi, Rosalia
Mandalari, Giuseppina
Cuzzocrea, Salvatore
Di Paola, Rosanna
Impellizzeri, Daniela
Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein
title Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein
title_full Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein
title_fullStr Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein
title_full_unstemmed Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein
title_short Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein
title_sort cashew (anacardium occidentale l.) nuts modulate the nrf2 and nlrp3 pathways in pancreas and lung after induction of acute pancreatitis by cerulein
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602264/
https://www.ncbi.nlm.nih.gov/pubmed/33066525
http://dx.doi.org/10.3390/antiox9100992
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