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Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines

BACKGROUND: Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet. METHODS: The present study was conducted on 54 healthy con...

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Autores principales: Gholamrezayi, Afsane, Mohamadinarab, Maryam, Rahbarinejad, Pegah, Fallah, Soudabeh, Barez, Shekufe Rezghi, Setayesh, Leila, Moradi, Nariman, Fadaei, Reza, Chamani, Elham, Tavakoli, Tahmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602304/
https://www.ncbi.nlm.nih.gov/pubmed/33126870
http://dx.doi.org/10.1186/s12944-020-01404-6
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author Gholamrezayi, Afsane
Mohamadinarab, Maryam
Rahbarinejad, Pegah
Fallah, Soudabeh
Barez, Shekufe Rezghi
Setayesh, Leila
Moradi, Nariman
Fadaei, Reza
Chamani, Elham
Tavakoli, Tahmine
author_facet Gholamrezayi, Afsane
Mohamadinarab, Maryam
Rahbarinejad, Pegah
Fallah, Soudabeh
Barez, Shekufe Rezghi
Setayesh, Leila
Moradi, Nariman
Fadaei, Reza
Chamani, Elham
Tavakoli, Tahmine
author_sort Gholamrezayi, Afsane
collection PubMed
description BACKGROUND: Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet. METHODS: The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn’s disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits. RESULTS: Metrnl concentration was considerably lower in both UC (85.25 ± 36.55 pg/mL) and CD (76.93 ± 27.92 pg/mL) patients in comparison to control (107.52 ± 35.33 pg/mL). In addition, it was seen that both patient groups have a decreased level of adiponectin compared to the controls. Besides that, the level of IL-6 and TNF-α were significantly greater in the patient groups. Moreover, the result showed that the level of Metrnl is inversely correlated with body mass index (BMI) in the controls and the patients. Metrnl levels are also inversely associated with IL-6, and TNF-α in both of the patient groups. CONCLUSIONS: The current study is the first one reporting the decreased levels of Metrnl in serum among patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process, although further studies are warranted to dissect the possible mechanism.
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spelling pubmed-76023042020-11-02 Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines Gholamrezayi, Afsane Mohamadinarab, Maryam Rahbarinejad, Pegah Fallah, Soudabeh Barez, Shekufe Rezghi Setayesh, Leila Moradi, Nariman Fadaei, Reza Chamani, Elham Tavakoli, Tahmine Lipids Health Dis Research BACKGROUND: Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet. METHODS: The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn’s disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits. RESULTS: Metrnl concentration was considerably lower in both UC (85.25 ± 36.55 pg/mL) and CD (76.93 ± 27.92 pg/mL) patients in comparison to control (107.52 ± 35.33 pg/mL). In addition, it was seen that both patient groups have a decreased level of adiponectin compared to the controls. Besides that, the level of IL-6 and TNF-α were significantly greater in the patient groups. Moreover, the result showed that the level of Metrnl is inversely correlated with body mass index (BMI) in the controls and the patients. Metrnl levels are also inversely associated with IL-6, and TNF-α in both of the patient groups. CONCLUSIONS: The current study is the first one reporting the decreased levels of Metrnl in serum among patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process, although further studies are warranted to dissect the possible mechanism. BioMed Central 2020-10-30 /pmc/articles/PMC7602304/ /pubmed/33126870 http://dx.doi.org/10.1186/s12944-020-01404-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Gholamrezayi, Afsane
Mohamadinarab, Maryam
Rahbarinejad, Pegah
Fallah, Soudabeh
Barez, Shekufe Rezghi
Setayesh, Leila
Moradi, Nariman
Fadaei, Reza
Chamani, Elham
Tavakoli, Tahmine
Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines
title Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines
title_full Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines
title_fullStr Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines
title_full_unstemmed Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines
title_short Characterization of the serum levels of Meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines
title_sort characterization of the serum levels of meteorin-like in patients with inflammatory bowel disease and its association with inflammatory cytokines
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602304/
https://www.ncbi.nlm.nih.gov/pubmed/33126870
http://dx.doi.org/10.1186/s12944-020-01404-6
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