The impact of different suturing techniques for abdominal fascia closure on the Interleukin-6 expressions in Rattus norvegicus

OBJECTIVE: Incisional hernia is a frequent complication of midline laparotomy. The suturing technique is an important determinant of the risk of developing an incisional hernia. Moreover, IL-6 has crucial roles in the wound-healing process. We aimed to compare the large stitch vs. small stitch techn...

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Autores principales: Prima, Heryu, Sofii, Imam, Fauzi, Aditya Rifqi, Dachlan, Ishandono, Gunadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602327/
https://www.ncbi.nlm.nih.gov/pubmed/33126892
http://dx.doi.org/10.1186/s13104-020-05349-y
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author Prima, Heryu
Sofii, Imam
Fauzi, Aditya Rifqi
Dachlan, Ishandono
Gunadi
author_facet Prima, Heryu
Sofii, Imam
Fauzi, Aditya Rifqi
Dachlan, Ishandono
Gunadi
author_sort Prima, Heryu
collection PubMed
description OBJECTIVE: Incisional hernia is a frequent complication of midline laparotomy. The suturing technique is an important determinant of the risk of developing an incisional hernia. Moreover, IL-6 has crucial roles in the wound-healing process. We aimed to compare the large stitch vs. small stitch technique for abdominal fascial closure on IL-6 expressions in rats. RESULTS: Twenty rats were used. The small stitch group received small tissue bites of 5 mm and the large stitch group received large bites of 10 mm. The incisions of fascia were closed by running sutures. Animals were euthanized on days 4 and 7. Histological sections of the tissue-embedded sutures were analyzed for IL-6 expressions. Two-way ANOVA showed that rats in the small stitch group had similar IL-6 expressions on days 4 and 7 to those in the large stitch group (p = 0.36). In conclusion, the IL-6 expressions are similar between the small and the large stitch groups, implying that different suturing techniques might not have an impact on the incisional hernia occurrence.
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spelling pubmed-76023272020-11-02 The impact of different suturing techniques for abdominal fascia closure on the Interleukin-6 expressions in Rattus norvegicus Prima, Heryu Sofii, Imam Fauzi, Aditya Rifqi Dachlan, Ishandono Gunadi BMC Res Notes Research Note OBJECTIVE: Incisional hernia is a frequent complication of midline laparotomy. The suturing technique is an important determinant of the risk of developing an incisional hernia. Moreover, IL-6 has crucial roles in the wound-healing process. We aimed to compare the large stitch vs. small stitch technique for abdominal fascial closure on IL-6 expressions in rats. RESULTS: Twenty rats were used. The small stitch group received small tissue bites of 5 mm and the large stitch group received large bites of 10 mm. The incisions of fascia were closed by running sutures. Animals were euthanized on days 4 and 7. Histological sections of the tissue-embedded sutures were analyzed for IL-6 expressions. Two-way ANOVA showed that rats in the small stitch group had similar IL-6 expressions on days 4 and 7 to those in the large stitch group (p = 0.36). In conclusion, the IL-6 expressions are similar between the small and the large stitch groups, implying that different suturing techniques might not have an impact on the incisional hernia occurrence. BioMed Central 2020-10-30 /pmc/articles/PMC7602327/ /pubmed/33126892 http://dx.doi.org/10.1186/s13104-020-05349-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Prima, Heryu
Sofii, Imam
Fauzi, Aditya Rifqi
Dachlan, Ishandono
Gunadi
The impact of different suturing techniques for abdominal fascia closure on the Interleukin-6 expressions in Rattus norvegicus
title The impact of different suturing techniques for abdominal fascia closure on the Interleukin-6 expressions in Rattus norvegicus
title_full The impact of different suturing techniques for abdominal fascia closure on the Interleukin-6 expressions in Rattus norvegicus
title_fullStr The impact of different suturing techniques for abdominal fascia closure on the Interleukin-6 expressions in Rattus norvegicus
title_full_unstemmed The impact of different suturing techniques for abdominal fascia closure on the Interleukin-6 expressions in Rattus norvegicus
title_short The impact of different suturing techniques for abdominal fascia closure on the Interleukin-6 expressions in Rattus norvegicus
title_sort impact of different suturing techniques for abdominal fascia closure on the interleukin-6 expressions in rattus norvegicus
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602327/
https://www.ncbi.nlm.nih.gov/pubmed/33126892
http://dx.doi.org/10.1186/s13104-020-05349-y
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