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The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes
Carbapenems are β-lactams antimicrobials presenting a broad activity spectrum and are considered as last-resort antibiotic. Since the 2000s, carbapenemase producing Enterobacterales (CPE) have emerged and are been quickly globally spreading. The global dissemination of carbapenemase encoding genes (...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602417/ https://www.ncbi.nlm.nih.gov/pubmed/33076221 http://dx.doi.org/10.3390/antibiotics9100699 |
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author | Hammer-Dedet, Florence Jumas-Bilak, Estelle Licznar-Fajardo, Patricia |
author_facet | Hammer-Dedet, Florence Jumas-Bilak, Estelle Licznar-Fajardo, Patricia |
author_sort | Hammer-Dedet, Florence |
collection | PubMed |
description | Carbapenems are β-lactams antimicrobials presenting a broad activity spectrum and are considered as last-resort antibiotic. Since the 2000s, carbapenemase producing Enterobacterales (CPE) have emerged and are been quickly globally spreading. The global dissemination of carbapenemase encoding genes (CEG) within clinical relevant bacteria is attributed in part to its location onto mobile genetic elements. During the last decade, carbapenemase producing bacteria have been isolated from non-human sources including the aquatic environment. Aquatic ecosystems are particularly impacted by anthropic activities, which conduce to a bidirectional exchange between aquatic environments and human beings and therefore the aquatic environment may constitute a hub for CPE and CEG. More recently, the isolation of autochtonous aquatic bacteria carrying acquired CEG have been reported and suggest that CEG exchange by horizontal gene transfer occurred between allochtonous and autochtonous bacteria. Hence, aquatic environment plays a central role in persistence, dissemination and emergence of CEG both within environmental ecosystem and human beings, and deserves to be studied with particular attention. |
format | Online Article Text |
id | pubmed-7602417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76024172020-11-01 The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes Hammer-Dedet, Florence Jumas-Bilak, Estelle Licznar-Fajardo, Patricia Antibiotics (Basel) Review Carbapenems are β-lactams antimicrobials presenting a broad activity spectrum and are considered as last-resort antibiotic. Since the 2000s, carbapenemase producing Enterobacterales (CPE) have emerged and are been quickly globally spreading. The global dissemination of carbapenemase encoding genes (CEG) within clinical relevant bacteria is attributed in part to its location onto mobile genetic elements. During the last decade, carbapenemase producing bacteria have been isolated from non-human sources including the aquatic environment. Aquatic ecosystems are particularly impacted by anthropic activities, which conduce to a bidirectional exchange between aquatic environments and human beings and therefore the aquatic environment may constitute a hub for CPE and CEG. More recently, the isolation of autochtonous aquatic bacteria carrying acquired CEG have been reported and suggest that CEG exchange by horizontal gene transfer occurred between allochtonous and autochtonous bacteria. Hence, aquatic environment plays a central role in persistence, dissemination and emergence of CEG both within environmental ecosystem and human beings, and deserves to be studied with particular attention. MDPI 2020-10-15 /pmc/articles/PMC7602417/ /pubmed/33076221 http://dx.doi.org/10.3390/antibiotics9100699 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hammer-Dedet, Florence Jumas-Bilak, Estelle Licznar-Fajardo, Patricia The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
title | The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
title_full | The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
title_fullStr | The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
title_full_unstemmed | The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
title_short | The Hydric Environment: A Hub for Clinically Relevant Carbapenemase Encoding Genes |
title_sort | hydric environment: a hub for clinically relevant carbapenemase encoding genes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602417/ https://www.ncbi.nlm.nih.gov/pubmed/33076221 http://dx.doi.org/10.3390/antibiotics9100699 |
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