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Long Term Dietary Restriction of Advanced Glycation End-Products (AGEs) in Older Adults with Type 2 Diabetes Is Feasible and Efficacious-Results from a Pilot RCT

Introduction: High serum concentrations of advanced glycation end-products (AGEs) in older adults and diabetics are associated with an increased risk of cognitive impairment. The aim of this pilot study was to assess the feasibility of long-term adherence to a dietary intervention designed to decrea...

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Autores principales: Lotan, Roni, Ganmore, Ithamar, Shelly, Shahar, Zacharia, Moran, Uribarri, Jaime, Beisswenger, Paul, Cai, Weijing, Troen, Aron M., Schnaider Beeri, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602440/
https://www.ncbi.nlm.nih.gov/pubmed/33076217
http://dx.doi.org/10.3390/nu12103143
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author Lotan, Roni
Ganmore, Ithamar
Shelly, Shahar
Zacharia, Moran
Uribarri, Jaime
Beisswenger, Paul
Cai, Weijing
Troen, Aron M.
Schnaider Beeri, Michal
author_facet Lotan, Roni
Ganmore, Ithamar
Shelly, Shahar
Zacharia, Moran
Uribarri, Jaime
Beisswenger, Paul
Cai, Weijing
Troen, Aron M.
Schnaider Beeri, Michal
author_sort Lotan, Roni
collection PubMed
description Introduction: High serum concentrations of advanced glycation end-products (AGEs) in older adults and diabetics are associated with an increased risk of cognitive impairment. The aim of this pilot study was to assess the feasibility of long-term adherence to a dietary intervention designed to decrease intake and exposure to circulating AGEs among older adults with type 2 diabetes. Methods: Herein, 75 participants were randomized to either a standard of care (SOC) control arm or to an intervention arm receiving instruction on reducing dietary AGEs intake. The primary outcome was a change in serum AGEs at the end of the intervention. Secondary and exploratory outcomes included adherence to diet and its association with circulating AGEs. Cognitive function and brain imaging were also assessed but were out of the scope of this article (ClinicalTrials.gov Identifier: NCT02739971). Results: The intervention resulted in a significant change over time in several serum AGEs compared to the SOC guidelines. Very high adherence (above 80%) to the AGE-lowering diet was associated with a greater reduction in serum AGEs levels. There were no significant differences between the two arms in any other metabolic markers. Conclusions: A long-term dietary intervention to reduce circulating AGEs is feasible in older adults with type 2 diabetes, especially in those who are highly adherent to the AGE-lowering diet.
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spelling pubmed-76024402020-11-01 Long Term Dietary Restriction of Advanced Glycation End-Products (AGEs) in Older Adults with Type 2 Diabetes Is Feasible and Efficacious-Results from a Pilot RCT Lotan, Roni Ganmore, Ithamar Shelly, Shahar Zacharia, Moran Uribarri, Jaime Beisswenger, Paul Cai, Weijing Troen, Aron M. Schnaider Beeri, Michal Nutrients Article Introduction: High serum concentrations of advanced glycation end-products (AGEs) in older adults and diabetics are associated with an increased risk of cognitive impairment. The aim of this pilot study was to assess the feasibility of long-term adherence to a dietary intervention designed to decrease intake and exposure to circulating AGEs among older adults with type 2 diabetes. Methods: Herein, 75 participants were randomized to either a standard of care (SOC) control arm or to an intervention arm receiving instruction on reducing dietary AGEs intake. The primary outcome was a change in serum AGEs at the end of the intervention. Secondary and exploratory outcomes included adherence to diet and its association with circulating AGEs. Cognitive function and brain imaging were also assessed but were out of the scope of this article (ClinicalTrials.gov Identifier: NCT02739971). Results: The intervention resulted in a significant change over time in several serum AGEs compared to the SOC guidelines. Very high adherence (above 80%) to the AGE-lowering diet was associated with a greater reduction in serum AGEs levels. There were no significant differences between the two arms in any other metabolic markers. Conclusions: A long-term dietary intervention to reduce circulating AGEs is feasible in older adults with type 2 diabetes, especially in those who are highly adherent to the AGE-lowering diet. MDPI 2020-10-15 /pmc/articles/PMC7602440/ /pubmed/33076217 http://dx.doi.org/10.3390/nu12103143 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lotan, Roni
Ganmore, Ithamar
Shelly, Shahar
Zacharia, Moran
Uribarri, Jaime
Beisswenger, Paul
Cai, Weijing
Troen, Aron M.
Schnaider Beeri, Michal
Long Term Dietary Restriction of Advanced Glycation End-Products (AGEs) in Older Adults with Type 2 Diabetes Is Feasible and Efficacious-Results from a Pilot RCT
title Long Term Dietary Restriction of Advanced Glycation End-Products (AGEs) in Older Adults with Type 2 Diabetes Is Feasible and Efficacious-Results from a Pilot RCT
title_full Long Term Dietary Restriction of Advanced Glycation End-Products (AGEs) in Older Adults with Type 2 Diabetes Is Feasible and Efficacious-Results from a Pilot RCT
title_fullStr Long Term Dietary Restriction of Advanced Glycation End-Products (AGEs) in Older Adults with Type 2 Diabetes Is Feasible and Efficacious-Results from a Pilot RCT
title_full_unstemmed Long Term Dietary Restriction of Advanced Glycation End-Products (AGEs) in Older Adults with Type 2 Diabetes Is Feasible and Efficacious-Results from a Pilot RCT
title_short Long Term Dietary Restriction of Advanced Glycation End-Products (AGEs) in Older Adults with Type 2 Diabetes Is Feasible and Efficacious-Results from a Pilot RCT
title_sort long term dietary restriction of advanced glycation end-products (ages) in older adults with type 2 diabetes is feasible and efficacious-results from a pilot rct
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602440/
https://www.ncbi.nlm.nih.gov/pubmed/33076217
http://dx.doi.org/10.3390/nu12103143
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