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Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions

The craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and cranium are often disrupted. While reconstructive...

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Autores principales: Oliver, Jeremie D., Madhoun, Wasila, Graham, Emily M., Hendrycks, Russell, Renouard, Maranda, Hu, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602501/
https://www.ncbi.nlm.nih.gov/pubmed/33076266
http://dx.doi.org/10.3390/jcm9103307
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author Oliver, Jeremie D.
Madhoun, Wasila
Graham, Emily M.
Hendrycks, Russell
Renouard, Maranda
Hu, Michael S.
author_facet Oliver, Jeremie D.
Madhoun, Wasila
Graham, Emily M.
Hendrycks, Russell
Renouard, Maranda
Hu, Michael S.
author_sort Oliver, Jeremie D.
collection PubMed
description The craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and cranium are often disrupted. While reconstructive techniques have long been innovated in this field, there are crucial limitations to the surgical restoration of craniomaxillofacial form and function. Fortunately, the rise of regenerative medicine and surgery has expanded the possibilities for patients affected with hard and soft tissue deficits, allowing for the controlled engineering and regeneration of patient-specific defects. In particular, stem cell therapy has emerged in recent years as an adjuvant treatment for the targeted regeneration of craniomaxillofacial structures. This review outlines the current state of the art in stem cell therapies utilized for the engineered restoration and regeneration of skeletal defects in the craniofacial region.
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spelling pubmed-76025012020-11-01 Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions Oliver, Jeremie D. Madhoun, Wasila Graham, Emily M. Hendrycks, Russell Renouard, Maranda Hu, Michael S. J Clin Med Review The craniofacial region comprises the most complex and intricate anatomical structures in the human body. As a result of developmental defects, traumatic injury, or neoplastic tissue formation, the functional and aesthetic intricacies of the face and cranium are often disrupted. While reconstructive techniques have long been innovated in this field, there are crucial limitations to the surgical restoration of craniomaxillofacial form and function. Fortunately, the rise of regenerative medicine and surgery has expanded the possibilities for patients affected with hard and soft tissue deficits, allowing for the controlled engineering and regeneration of patient-specific defects. In particular, stem cell therapy has emerged in recent years as an adjuvant treatment for the targeted regeneration of craniomaxillofacial structures. This review outlines the current state of the art in stem cell therapies utilized for the engineered restoration and regeneration of skeletal defects in the craniofacial region. MDPI 2020-10-15 /pmc/articles/PMC7602501/ /pubmed/33076266 http://dx.doi.org/10.3390/jcm9103307 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oliver, Jeremie D.
Madhoun, Wasila
Graham, Emily M.
Hendrycks, Russell
Renouard, Maranda
Hu, Michael S.
Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title_full Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title_fullStr Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title_full_unstemmed Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title_short Stem Cells Regenerating the Craniofacial Skeleton: Current State-Of-The-Art and Future Directions
title_sort stem cells regenerating the craniofacial skeleton: current state-of-the-art and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602501/
https://www.ncbi.nlm.nih.gov/pubmed/33076266
http://dx.doi.org/10.3390/jcm9103307
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