PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice

Pregnane X receptor (PXR) is a liver-enriched xenobiotic-responsive transcription factor. Although recent studies suggest that PXR shows anti-inflammatory effects by suppressing nuclear factor kappa B (NF-κB), the detailed mechanism remains unclear. In this study, we aimed to elucidate this mechanis...

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Detalles Bibliográficos
Autores principales: Okamura, Maya, Shizu, Ryota, Abe, Taiki, Kodama, Susumu, Hosaka, Takuomi, Sasaki, Takamitsu, Yoshinari, Kouichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602528/
https://www.ncbi.nlm.nih.gov/pubmed/33076328
http://dx.doi.org/10.3390/cells9102296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602528/
https://www.ncbi.nlm.nih.gov/pubmed/33076328
http://dx.doi.org/10.3390/cells9102296

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