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Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study
ABO blood groups have been implicated as potential risk factors for various diseases. However, no study has investigated the association between sepsis mortality and ABO blood types. We aimed to evaluate the impact of these blood types on mortality in patients with sepsis and septic shock. This retr...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602578/ https://www.ncbi.nlm.nih.gov/pubmed/33076323 http://dx.doi.org/10.3390/diagnostics10100826 |
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author | Hasegawa, Daisuke Nishida, Kazuki Kawaji, Takahiro Hara, Yoshitaka Shimomura, Yasuyo Moriyama, Kazuhiro Niimi, Daisuke Kuriyama, Naohide Shintani, Ayumi Komura, Hidefumi Nishida, Osamu |
author_facet | Hasegawa, Daisuke Nishida, Kazuki Kawaji, Takahiro Hara, Yoshitaka Shimomura, Yasuyo Moriyama, Kazuhiro Niimi, Daisuke Kuriyama, Naohide Shintani, Ayumi Komura, Hidefumi Nishida, Osamu |
author_sort | Hasegawa, Daisuke |
collection | PubMed |
description | ABO blood groups have been implicated as potential risk factors for various diseases. However, no study has investigated the association between sepsis mortality and ABO blood types. We aimed to evaluate the impact of these blood types on mortality in patients with sepsis and septic shock. This retrospective observational study was conducted at two general hospitals in Japan. Patients diagnosed with sepsis or septic shock were included and divided into four groups based on blood type (O, A, B, and AB). The association between type O vs. other types and 28- and 90-day mortalities was evaluated using multivariate logistic regression analysis adjusted for age, sex, and Sequential (Sepsis-related) Organ Failure Assessment score. This study included 415 patients, of whom 131 (31.6%), 171 (41.2%), 81 (19.5%), and 32 (7.7%) had type O, A, B, and AB, respectively. Blood type O was not associated with 28-day (odds ratio: 1.7 p = 0.08) or 90-day mortality (odds ratio: 1.53, p = 0.091). However, type O was significantly associated with higher 90-day mortality (odds ratio: 3.26, p = 0.009) in patients with septic shock. The role of ABO blood type in risk stratification for septic shock and the mechanisms that potentially affect the prognosis of sepsis patients need further investigation. |
format | Online Article Text |
id | pubmed-7602578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76025782020-11-01 Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study Hasegawa, Daisuke Nishida, Kazuki Kawaji, Takahiro Hara, Yoshitaka Shimomura, Yasuyo Moriyama, Kazuhiro Niimi, Daisuke Kuriyama, Naohide Shintani, Ayumi Komura, Hidefumi Nishida, Osamu Diagnostics (Basel) Article ABO blood groups have been implicated as potential risk factors for various diseases. However, no study has investigated the association between sepsis mortality and ABO blood types. We aimed to evaluate the impact of these blood types on mortality in patients with sepsis and septic shock. This retrospective observational study was conducted at two general hospitals in Japan. Patients diagnosed with sepsis or septic shock were included and divided into four groups based on blood type (O, A, B, and AB). The association between type O vs. other types and 28- and 90-day mortalities was evaluated using multivariate logistic regression analysis adjusted for age, sex, and Sequential (Sepsis-related) Organ Failure Assessment score. This study included 415 patients, of whom 131 (31.6%), 171 (41.2%), 81 (19.5%), and 32 (7.7%) had type O, A, B, and AB, respectively. Blood type O was not associated with 28-day (odds ratio: 1.7 p = 0.08) or 90-day mortality (odds ratio: 1.53, p = 0.091). However, type O was significantly associated with higher 90-day mortality (odds ratio: 3.26, p = 0.009) in patients with septic shock. The role of ABO blood type in risk stratification for septic shock and the mechanisms that potentially affect the prognosis of sepsis patients need further investigation. MDPI 2020-10-15 /pmc/articles/PMC7602578/ /pubmed/33076323 http://dx.doi.org/10.3390/diagnostics10100826 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hasegawa, Daisuke Nishida, Kazuki Kawaji, Takahiro Hara, Yoshitaka Shimomura, Yasuyo Moriyama, Kazuhiro Niimi, Daisuke Kuriyama, Naohide Shintani, Ayumi Komura, Hidefumi Nishida, Osamu Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study |
title | Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study |
title_full | Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study |
title_fullStr | Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study |
title_full_unstemmed | Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study |
title_short | Impact of Blood Type O on Mortality of Sepsis Patients: A Multicenter Retrospective Observational Study |
title_sort | impact of blood type o on mortality of sepsis patients: a multicenter retrospective observational study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602578/ https://www.ncbi.nlm.nih.gov/pubmed/33076323 http://dx.doi.org/10.3390/diagnostics10100826 |
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