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Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid

The Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) was introduced for classifying suspected hepatocellular carcinoma (HCC). However, it cannot be applied to Sonazoid. We assessed the diagnostic usefulness of a modified CEUS LI-RADS for HCC and non-HCC malignancie...

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Autores principales: Sugimoto, Katsutoshi, Kakegawa, Tatsuya, Takahashi, Hiroshi, Tomita, Yusuke, Abe, Masakazu, Yoshimasu, Yu, Takeuchi, Hirohito, Kasai, Yoshitaka, Itoi, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602639/
https://www.ncbi.nlm.nih.gov/pubmed/33076435
http://dx.doi.org/10.3390/diagnostics10100828
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author Sugimoto, Katsutoshi
Kakegawa, Tatsuya
Takahashi, Hiroshi
Tomita, Yusuke
Abe, Masakazu
Yoshimasu, Yu
Takeuchi, Hirohito
Kasai, Yoshitaka
Itoi, Takao
author_facet Sugimoto, Katsutoshi
Kakegawa, Tatsuya
Takahashi, Hiroshi
Tomita, Yusuke
Abe, Masakazu
Yoshimasu, Yu
Takeuchi, Hirohito
Kasai, Yoshitaka
Itoi, Takao
author_sort Sugimoto, Katsutoshi
collection PubMed
description The Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) was introduced for classifying suspected hepatocellular carcinoma (HCC). However, it cannot be applied to Sonazoid. We assessed the diagnostic usefulness of a modified CEUS LI-RADS for HCC and non-HCC malignancies based on sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Patients with chronic liver disease at risk for HCC were evaluated retrospectively. Nodules ≥1 cm with arterial phase hyperenhancement, no early washout (within 60 s), and contrast defects in the Kupffer phase were classified as LR-5. Nodules showing early washout, contrast defects in the Kupffer phase, and/or rim enhancement were classified as LR-M. A total of 104 nodules in 104 patients (median age: 70.0 years; interquartile range: 54.5–78.0 years; 74 men) were evaluated. The 48 (46.2%) LR-5 lesions included 45 HCCs, 2 high-flow hemangiomas, and 1 adrenal rest tumor. The PPV of LR-5 for HCC was 93.8% (95% confidence interval (CI): 82.8–98.7%). The 22 (21.2%) LR-M lesions included 16 non-HCC malignancies and 6 HCCs. The PPV of LR-M for non-HCC malignancies, including six intrahepatic cholangiocarcinomas, was 100% (95% CI: 69.8–100%). In conclusion, in the modified CEUS LI-RADS for Sonazoid, LR-5 and LR-M are good predictors of HCC and non-HCC malignancies, respectively.
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spelling pubmed-76026392020-11-01 Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid Sugimoto, Katsutoshi Kakegawa, Tatsuya Takahashi, Hiroshi Tomita, Yusuke Abe, Masakazu Yoshimasu, Yu Takeuchi, Hirohito Kasai, Yoshitaka Itoi, Takao Diagnostics (Basel) Article The Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS) was introduced for classifying suspected hepatocellular carcinoma (HCC). However, it cannot be applied to Sonazoid. We assessed the diagnostic usefulness of a modified CEUS LI-RADS for HCC and non-HCC malignancies based on sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Patients with chronic liver disease at risk for HCC were evaluated retrospectively. Nodules ≥1 cm with arterial phase hyperenhancement, no early washout (within 60 s), and contrast defects in the Kupffer phase were classified as LR-5. Nodules showing early washout, contrast defects in the Kupffer phase, and/or rim enhancement were classified as LR-M. A total of 104 nodules in 104 patients (median age: 70.0 years; interquartile range: 54.5–78.0 years; 74 men) were evaluated. The 48 (46.2%) LR-5 lesions included 45 HCCs, 2 high-flow hemangiomas, and 1 adrenal rest tumor. The PPV of LR-5 for HCC was 93.8% (95% confidence interval (CI): 82.8–98.7%). The 22 (21.2%) LR-M lesions included 16 non-HCC malignancies and 6 HCCs. The PPV of LR-M for non-HCC malignancies, including six intrahepatic cholangiocarcinomas, was 100% (95% CI: 69.8–100%). In conclusion, in the modified CEUS LI-RADS for Sonazoid, LR-5 and LR-M are good predictors of HCC and non-HCC malignancies, respectively. MDPI 2020-10-15 /pmc/articles/PMC7602639/ /pubmed/33076435 http://dx.doi.org/10.3390/diagnostics10100828 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sugimoto, Katsutoshi
Kakegawa, Tatsuya
Takahashi, Hiroshi
Tomita, Yusuke
Abe, Masakazu
Yoshimasu, Yu
Takeuchi, Hirohito
Kasai, Yoshitaka
Itoi, Takao
Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid
title Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid
title_full Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid
title_fullStr Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid
title_full_unstemmed Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid
title_short Usefulness of Modified CEUS LI-RADS for the Diagnosis of Hepatocellular Carcinoma Using Sonazoid
title_sort usefulness of modified ceus li-rads for the diagnosis of hepatocellular carcinoma using sonazoid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602639/
https://www.ncbi.nlm.nih.gov/pubmed/33076435
http://dx.doi.org/10.3390/diagnostics10100828
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