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Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma
Koala retrovirus (KoRV) is believed to be in an active state of endogenization into the koala genome. KoRV is present as both an endogenous and exogenous infection in all koalas in northern Australia. KoRV has been linked to koala pathologies including neoplasia and increased susceptibility to Chlam...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602773/ https://www.ncbi.nlm.nih.gov/pubmed/33129323 http://dx.doi.org/10.1186/s12985-020-01442-7 |
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author | Olagoke, Olusola Quigley, Bonnie L. Timms, Peter |
author_facet | Olagoke, Olusola Quigley, Bonnie L. Timms, Peter |
author_sort | Olagoke, Olusola |
collection | PubMed |
description | Koala retrovirus (KoRV) is believed to be in an active state of endogenization into the koala genome. KoRV is present as both an endogenous and exogenous infection in all koalas in northern Australia. KoRV has been linked to koala pathologies including neoplasia and increased susceptibility to Chlamydia. A KoRV vaccine recently trialled in 10 northern koalas improved antibody response and reduced viral load. This communication reports the expression of key immune genes underlining the innate and adaptive immune response to vaccination in these northern koalas. The results showed that prior to vaccination, IL-8 was expressed at the highest levels, with at least 200-fold greater expression compared to other cytokines, while CD8 mRNA expression was significantly higher than CD4 mRNA expression level. Interferon-γ was up-regulated at both 4- and 8-weeks post-vaccination while IL-8 was down-regulated at 8-weeks post-vaccination. |
format | Online Article Text |
id | pubmed-7602773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76027732020-11-02 Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma Olagoke, Olusola Quigley, Bonnie L. Timms, Peter Virol J Short Report Koala retrovirus (KoRV) is believed to be in an active state of endogenization into the koala genome. KoRV is present as both an endogenous and exogenous infection in all koalas in northern Australia. KoRV has been linked to koala pathologies including neoplasia and increased susceptibility to Chlamydia. A KoRV vaccine recently trialled in 10 northern koalas improved antibody response and reduced viral load. This communication reports the expression of key immune genes underlining the innate and adaptive immune response to vaccination in these northern koalas. The results showed that prior to vaccination, IL-8 was expressed at the highest levels, with at least 200-fold greater expression compared to other cytokines, while CD8 mRNA expression was significantly higher than CD4 mRNA expression level. Interferon-γ was up-regulated at both 4- and 8-weeks post-vaccination while IL-8 was down-regulated at 8-weeks post-vaccination. BioMed Central 2020-10-31 /pmc/articles/PMC7602773/ /pubmed/33129323 http://dx.doi.org/10.1186/s12985-020-01442-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Short Report Olagoke, Olusola Quigley, Bonnie L. Timms, Peter Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma |
title | Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma |
title_full | Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma |
title_fullStr | Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma |
title_full_unstemmed | Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma |
title_short | Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma |
title_sort | koalas vaccinated against koala retrovirus respond by producing increased levels of interferon-gamma |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602773/ https://www.ncbi.nlm.nih.gov/pubmed/33129323 http://dx.doi.org/10.1186/s12985-020-01442-7 |
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