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Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation

The self-assembly of amphiphilic diblock copolymers into polymeric vesicles, commonly known as polymersomes, results in a versatile system for a variety of applications including drug delivery and microreactors. In this study, we show that the incorporation of hydrophobic plasmonic nanoparticles wit...

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Detalles Bibliográficos
Autores principales: DiSalvo, Gina M., Robinson, Abby R., Aly, Mohamed S., Hoglund, Eric R., O’Malley, Sean M., Griepenburg, Julianne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602809/
https://www.ncbi.nlm.nih.gov/pubmed/33081104
http://dx.doi.org/10.3390/polym12102381
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author DiSalvo, Gina M.
Robinson, Abby R.
Aly, Mohamed S.
Hoglund, Eric R.
O’Malley, Sean M.
Griepenburg, Julianne C.
author_facet DiSalvo, Gina M.
Robinson, Abby R.
Aly, Mohamed S.
Hoglund, Eric R.
O’Malley, Sean M.
Griepenburg, Julianne C.
author_sort DiSalvo, Gina M.
collection PubMed
description The self-assembly of amphiphilic diblock copolymers into polymeric vesicles, commonly known as polymersomes, results in a versatile system for a variety of applications including drug delivery and microreactors. In this study, we show that the incorporation of hydrophobic plasmonic nanoparticles within the polymersome membrane facilitates light-stimulated release of vesicle encapsulants. This work seeks to achieve tunable, triggered release with non-invasive, spatiotemporal control using single-pulse irradiation. Gold nanoparticles (AuNPs) are incorporated as photosensitizers into the hydrophobic membrane of micron-scale polymersomes and the cargo release profile is controlled by varying the pulse energy and nanoparticle concentration. We have demonstrated the ability to achieve immediate vesicle rupture as well as vesicle poration resulting in temporal cargo diffusion. Additionally, changing the pulse duration, from femtosecond to nanosecond, provides mechanistic insight into the photothermal and photomechanical contributors that govern membrane disruption in this polymer–nanoparticle hybrid system.
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spelling pubmed-76028092020-11-01 Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation DiSalvo, Gina M. Robinson, Abby R. Aly, Mohamed S. Hoglund, Eric R. O’Malley, Sean M. Griepenburg, Julianne C. Polymers (Basel) Article The self-assembly of amphiphilic diblock copolymers into polymeric vesicles, commonly known as polymersomes, results in a versatile system for a variety of applications including drug delivery and microreactors. In this study, we show that the incorporation of hydrophobic plasmonic nanoparticles within the polymersome membrane facilitates light-stimulated release of vesicle encapsulants. This work seeks to achieve tunable, triggered release with non-invasive, spatiotemporal control using single-pulse irradiation. Gold nanoparticles (AuNPs) are incorporated as photosensitizers into the hydrophobic membrane of micron-scale polymersomes and the cargo release profile is controlled by varying the pulse energy and nanoparticle concentration. We have demonstrated the ability to achieve immediate vesicle rupture as well as vesicle poration resulting in temporal cargo diffusion. Additionally, changing the pulse duration, from femtosecond to nanosecond, provides mechanistic insight into the photothermal and photomechanical contributors that govern membrane disruption in this polymer–nanoparticle hybrid system. MDPI 2020-10-16 /pmc/articles/PMC7602809/ /pubmed/33081104 http://dx.doi.org/10.3390/polym12102381 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
DiSalvo, Gina M.
Robinson, Abby R.
Aly, Mohamed S.
Hoglund, Eric R.
O’Malley, Sean M.
Griepenburg, Julianne C.
Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation
title Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation
title_full Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation
title_fullStr Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation
title_full_unstemmed Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation
title_short Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation
title_sort polymersome poration and rupture mediated by plasmonic nanoparticles in response to single-pulse irradiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602809/
https://www.ncbi.nlm.nih.gov/pubmed/33081104
http://dx.doi.org/10.3390/polym12102381
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