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Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension

Fetal undernutrition programs hypertension and cardiovascular diseases, and resistance artery remodeling may be a contributing factor. We aimed to assess if fetal undernutrition induces resistance artery remodeling and the relationship with hypertension. Sprague–Dawley dams were fed ad libitum (Cont...

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Autores principales: Gutiérrez-Arzapalo, Perla Y., Rodríguez-Rodríguez, Pilar, Ramiro-Cortijo, David, Gil-Ortega, Marta, Somoza, Beatriz, de Pablo, Ángel Luis López, González, Maria del Carmen, Arribas, Silvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602844/
https://www.ncbi.nlm.nih.gov/pubmed/33081182
http://dx.doi.org/10.3390/biomedicines8100424
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author Gutiérrez-Arzapalo, Perla Y.
Rodríguez-Rodríguez, Pilar
Ramiro-Cortijo, David
Gil-Ortega, Marta
Somoza, Beatriz
de Pablo, Ángel Luis López
González, Maria del Carmen
Arribas, Silvia M.
author_facet Gutiérrez-Arzapalo, Perla Y.
Rodríguez-Rodríguez, Pilar
Ramiro-Cortijo, David
Gil-Ortega, Marta
Somoza, Beatriz
de Pablo, Ángel Luis López
González, Maria del Carmen
Arribas, Silvia M.
author_sort Gutiérrez-Arzapalo, Perla Y.
collection PubMed
description Fetal undernutrition programs hypertension and cardiovascular diseases, and resistance artery remodeling may be a contributing factor. We aimed to assess if fetal undernutrition induces resistance artery remodeling and the relationship with hypertension. Sprague–Dawley dams were fed ad libitum (Control) or with 50% of control intake between days 11 and 21 of gestation (maternal undernutrition, MUN). In six-month-old male and female offspring we assessed blood pressure (anesthetized and tail-cuff); mesenteric resistance artery (MRA) structure and mechanics (pressure myography), cellular and internal elastic lamina (IEL) organization (confocal microscopy) and plasma MMP-2 and MMP-9 activity (zymography). Systolic blood pressure (SBP, tail-cuff) and plasma MMP activity were assessed in 18-month-old rats. At the age of six months MUN males exhibited significantly higher blood pressure (anesthetized or tail-cuff) and plasma MMP-9 activity, while MUN females did not exhibit significant differences, compared to sex-matched controls. MRA from 6-month-old MUN males and females showed a smaller diameter, reduced adventitial, smooth muscle cell density and IEL fenestra area, and a leftward shift of stress-strain curves. At the age of eighteen months SBP and MMP-9 activity were higher in both MUN males and females, compared to sex-matched controls. These data suggest that fetal undernutrition induces MRA inward eutrophic remodeling and stiffness in both sexes, independent of blood pressure level. Resistance artery structural and mechanical alterations can participate in the development of hypertension in aged females and may contribute to adverse cardiovascular events associated with low birth weight in both sexes.
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spelling pubmed-76028442020-11-01 Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension Gutiérrez-Arzapalo, Perla Y. Rodríguez-Rodríguez, Pilar Ramiro-Cortijo, David Gil-Ortega, Marta Somoza, Beatriz de Pablo, Ángel Luis López González, Maria del Carmen Arribas, Silvia M. Biomedicines Article Fetal undernutrition programs hypertension and cardiovascular diseases, and resistance artery remodeling may be a contributing factor. We aimed to assess if fetal undernutrition induces resistance artery remodeling and the relationship with hypertension. Sprague–Dawley dams were fed ad libitum (Control) or with 50% of control intake between days 11 and 21 of gestation (maternal undernutrition, MUN). In six-month-old male and female offspring we assessed blood pressure (anesthetized and tail-cuff); mesenteric resistance artery (MRA) structure and mechanics (pressure myography), cellular and internal elastic lamina (IEL) organization (confocal microscopy) and plasma MMP-2 and MMP-9 activity (zymography). Systolic blood pressure (SBP, tail-cuff) and plasma MMP activity were assessed in 18-month-old rats. At the age of six months MUN males exhibited significantly higher blood pressure (anesthetized or tail-cuff) and plasma MMP-9 activity, while MUN females did not exhibit significant differences, compared to sex-matched controls. MRA from 6-month-old MUN males and females showed a smaller diameter, reduced adventitial, smooth muscle cell density and IEL fenestra area, and a leftward shift of stress-strain curves. At the age of eighteen months SBP and MMP-9 activity were higher in both MUN males and females, compared to sex-matched controls. These data suggest that fetal undernutrition induces MRA inward eutrophic remodeling and stiffness in both sexes, independent of blood pressure level. Resistance artery structural and mechanical alterations can participate in the development of hypertension in aged females and may contribute to adverse cardiovascular events associated with low birth weight in both sexes. MDPI 2020-10-16 /pmc/articles/PMC7602844/ /pubmed/33081182 http://dx.doi.org/10.3390/biomedicines8100424 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gutiérrez-Arzapalo, Perla Y.
Rodríguez-Rodríguez, Pilar
Ramiro-Cortijo, David
Gil-Ortega, Marta
Somoza, Beatriz
de Pablo, Ángel Luis López
González, Maria del Carmen
Arribas, Silvia M.
Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension
title Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension
title_full Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension
title_fullStr Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension
title_full_unstemmed Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension
title_short Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension
title_sort fetal undernutrition induces resistance artery remodeling and stiffness in male and female rats independent of hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602844/
https://www.ncbi.nlm.nih.gov/pubmed/33081182
http://dx.doi.org/10.3390/biomedicines8100424
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