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Genomic Instability in Circulating Tumor Cells
SIMPLE SUMMARY: In this review, we focus on recent advances in the detection and quantification of tumor cell heterogeneity and genomic instability of CTCs and the contribution of chromosome instability studies to genetic heterogeneity in CTCs at the single-CTC level. ABSTRACT: Circulating tumor cel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602879/ https://www.ncbi.nlm.nih.gov/pubmed/33081135 http://dx.doi.org/10.3390/cancers12103001 |
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author | Freitas, Monique Oliveira Gartner, John Rangel-Pozzo, Aline Mai, Sabine |
author_facet | Freitas, Monique Oliveira Gartner, John Rangel-Pozzo, Aline Mai, Sabine |
author_sort | Freitas, Monique Oliveira |
collection | PubMed |
description | SIMPLE SUMMARY: In this review, we focus on recent advances in the detection and quantification of tumor cell heterogeneity and genomic instability of CTCs and the contribution of chromosome instability studies to genetic heterogeneity in CTCs at the single-CTC level. ABSTRACT: Circulating tumor cells (CTCs) can promote distant metastases and can be obtained through minimally invasive liquid biopsy for clinical assessment in cancer patients. Having both genomic heterogeneity and instability as common features, the genetic characterization of CTCs can serve as a powerful tool for a better understanding of the molecular changes occurring at tumor initiation and during tumor progression/metastasis. In this review, we will highlight recent advances in the detection and quantification of tumor cell heterogeneity and genomic instability in CTCs. We will focus on the contribution of chromosome instability studies to genetic heterogeneity in CTCs at the single-CTC level by discussing data from different cancer subtypes and their impact on diagnosis and precision medicine. |
format | Online Article Text |
id | pubmed-7602879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76028792020-11-01 Genomic Instability in Circulating Tumor Cells Freitas, Monique Oliveira Gartner, John Rangel-Pozzo, Aline Mai, Sabine Cancers (Basel) Review SIMPLE SUMMARY: In this review, we focus on recent advances in the detection and quantification of tumor cell heterogeneity and genomic instability of CTCs and the contribution of chromosome instability studies to genetic heterogeneity in CTCs at the single-CTC level. ABSTRACT: Circulating tumor cells (CTCs) can promote distant metastases and can be obtained through minimally invasive liquid biopsy for clinical assessment in cancer patients. Having both genomic heterogeneity and instability as common features, the genetic characterization of CTCs can serve as a powerful tool for a better understanding of the molecular changes occurring at tumor initiation and during tumor progression/metastasis. In this review, we will highlight recent advances in the detection and quantification of tumor cell heterogeneity and genomic instability in CTCs. We will focus on the contribution of chromosome instability studies to genetic heterogeneity in CTCs at the single-CTC level by discussing data from different cancer subtypes and their impact on diagnosis and precision medicine. MDPI 2020-10-16 /pmc/articles/PMC7602879/ /pubmed/33081135 http://dx.doi.org/10.3390/cancers12103001 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Freitas, Monique Oliveira Gartner, John Rangel-Pozzo, Aline Mai, Sabine Genomic Instability in Circulating Tumor Cells |
title | Genomic Instability in Circulating Tumor Cells |
title_full | Genomic Instability in Circulating Tumor Cells |
title_fullStr | Genomic Instability in Circulating Tumor Cells |
title_full_unstemmed | Genomic Instability in Circulating Tumor Cells |
title_short | Genomic Instability in Circulating Tumor Cells |
title_sort | genomic instability in circulating tumor cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602879/ https://www.ncbi.nlm.nih.gov/pubmed/33081135 http://dx.doi.org/10.3390/cancers12103001 |
work_keys_str_mv | AT freitasmoniqueoliveira genomicinstabilityincirculatingtumorcells AT gartnerjohn genomicinstabilityincirculatingtumorcells AT rangelpozzoaline genomicinstabilityincirculatingtumorcells AT maisabine genomicinstabilityincirculatingtumorcells |