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Auditory and Somatosensory P3 Are Complementary for the Assessment of Patients with Disorders of Consciousness
The evaluation of the level of consciousness in patients with disorders of consciousness (DOC) is primarily based on behavioural assessments. Patients with unresponsive wakefulness syndrome (UWS) do not show any sign of awareness of their environment, while minimally conscious state (MCS) patients s...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602953/ https://www.ncbi.nlm.nih.gov/pubmed/33080842 http://dx.doi.org/10.3390/brainsci10100748 |
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author | Annen, Jitka Mertel, Isabella Xu, Ren Chatelle, Camille Lesenfants, Damien Ortner, Rupert Bonin, Estelle A.C. Guger, Christoph Laureys, Steven Müller, Friedemann |
author_facet | Annen, Jitka Mertel, Isabella Xu, Ren Chatelle, Camille Lesenfants, Damien Ortner, Rupert Bonin, Estelle A.C. Guger, Christoph Laureys, Steven Müller, Friedemann |
author_sort | Annen, Jitka |
collection | PubMed |
description | The evaluation of the level of consciousness in patients with disorders of consciousness (DOC) is primarily based on behavioural assessments. Patients with unresponsive wakefulness syndrome (UWS) do not show any sign of awareness of their environment, while minimally conscious state (MCS) patients show reproducible but fluctuating signs of awareness. Some patients, although with remaining cognitive abilities, are not able to exhibit overt voluntary responses at the bedside and may be misdiagnosed as UWS. Several studies investigated functional neuroimaging and neurophysiology as an additional tool to evaluate the level of consciousness and to detect covert command following in DOC. Most of these studies are based on auditory stimulation, neglecting patients suffering from decreased or absent hearing abilities. In the present study, we aim to assess the response to a P3-based paradigm in 40 patients with DOC and 12 healthy participants using auditory (AEP) and vibrotactile (VTP) stimulation. To this end, an EEG-based brain-computer interface was used at DOC patient’s bedside. We compared the significance of the P3 performance (i.e., the interpretation of significance of the evoked P3 response) as obtained by ‘direct processing’ (i.e., theoretical-based significance threshold) and ‘offline processing’ (i.e., permutation-based single subject level threshold). We evaluated whether the P3 performances were dependent on clinical variables such as diagnosis (UWS and MCS), aetiology and time since injury. Last we tested the dependency of AEP and VTP performances at the single subject level. Direct processing tends to overestimate P3 performance. We did not find any difference in the presence of a P3 performance according to the level of consciousness (UWS vs. MCS) or the aetiology (traumatic vs. non-traumatic brain injury). The performance achieved at the AEP paradigm was independent from what was achieved at the VTP paradigm, indicating that some patients performed better on the AEP task while others performed better on the VTP task. Our results support the importance of using multimodal approaches in the assessment of DOC patients in order to optimise the evaluation of patient’s abilities. |
format | Online Article Text |
id | pubmed-7602953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76029532020-11-01 Auditory and Somatosensory P3 Are Complementary for the Assessment of Patients with Disorders of Consciousness Annen, Jitka Mertel, Isabella Xu, Ren Chatelle, Camille Lesenfants, Damien Ortner, Rupert Bonin, Estelle A.C. Guger, Christoph Laureys, Steven Müller, Friedemann Brain Sci Article The evaluation of the level of consciousness in patients with disorders of consciousness (DOC) is primarily based on behavioural assessments. Patients with unresponsive wakefulness syndrome (UWS) do not show any sign of awareness of their environment, while minimally conscious state (MCS) patients show reproducible but fluctuating signs of awareness. Some patients, although with remaining cognitive abilities, are not able to exhibit overt voluntary responses at the bedside and may be misdiagnosed as UWS. Several studies investigated functional neuroimaging and neurophysiology as an additional tool to evaluate the level of consciousness and to detect covert command following in DOC. Most of these studies are based on auditory stimulation, neglecting patients suffering from decreased or absent hearing abilities. In the present study, we aim to assess the response to a P3-based paradigm in 40 patients with DOC and 12 healthy participants using auditory (AEP) and vibrotactile (VTP) stimulation. To this end, an EEG-based brain-computer interface was used at DOC patient’s bedside. We compared the significance of the P3 performance (i.e., the interpretation of significance of the evoked P3 response) as obtained by ‘direct processing’ (i.e., theoretical-based significance threshold) and ‘offline processing’ (i.e., permutation-based single subject level threshold). We evaluated whether the P3 performances were dependent on clinical variables such as diagnosis (UWS and MCS), aetiology and time since injury. Last we tested the dependency of AEP and VTP performances at the single subject level. Direct processing tends to overestimate P3 performance. We did not find any difference in the presence of a P3 performance according to the level of consciousness (UWS vs. MCS) or the aetiology (traumatic vs. non-traumatic brain injury). The performance achieved at the AEP paradigm was independent from what was achieved at the VTP paradigm, indicating that some patients performed better on the AEP task while others performed better on the VTP task. Our results support the importance of using multimodal approaches in the assessment of DOC patients in order to optimise the evaluation of patient’s abilities. MDPI 2020-10-17 /pmc/articles/PMC7602953/ /pubmed/33080842 http://dx.doi.org/10.3390/brainsci10100748 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Annen, Jitka Mertel, Isabella Xu, Ren Chatelle, Camille Lesenfants, Damien Ortner, Rupert Bonin, Estelle A.C. Guger, Christoph Laureys, Steven Müller, Friedemann Auditory and Somatosensory P3 Are Complementary for the Assessment of Patients with Disorders of Consciousness |
title | Auditory and Somatosensory P3 Are Complementary for the Assessment of Patients with Disorders of Consciousness |
title_full | Auditory and Somatosensory P3 Are Complementary for the Assessment of Patients with Disorders of Consciousness |
title_fullStr | Auditory and Somatosensory P3 Are Complementary for the Assessment of Patients with Disorders of Consciousness |
title_full_unstemmed | Auditory and Somatosensory P3 Are Complementary for the Assessment of Patients with Disorders of Consciousness |
title_short | Auditory and Somatosensory P3 Are Complementary for the Assessment of Patients with Disorders of Consciousness |
title_sort | auditory and somatosensory p3 are complementary for the assessment of patients with disorders of consciousness |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602953/ https://www.ncbi.nlm.nih.gov/pubmed/33080842 http://dx.doi.org/10.3390/brainsci10100748 |
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