Calmodulin Directly Interacts with the Cx43 Carboxyl-Terminus and Cytoplasmic Loop Containing Three ODDD-Linked Mutants (M147T, R148Q, and T154A) that Retain α-Helical Structure, but Exhibit Loss-of-Function and Cellular Trafficking Defects

The autosomal-dominant pleiotropic disorder called oculodentodigital dysplasia (ODDD) is caused by mutations in the gap junction protein Cx43. Of the 73 mutations identified to date, over one-third are localized in the cytoplasmic loop (Cx43CL) domain. Here, we determined the mechanism by which thre...

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Detalles Bibliográficos
Autores principales: Zheng, Li, Chenavas, Sylvie, Kieken, Fabien, Trease, Andrew, Brownell, Sarah, Anbanandam, Asokan, Sorgen, Paul L., Spagnol, Gaelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602980/
https://www.ncbi.nlm.nih.gov/pubmed/33080786
http://dx.doi.org/10.3390/biom10101452

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