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Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women
While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels <62.5 nm...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602985/ https://www.ncbi.nlm.nih.gov/pubmed/33080839 http://dx.doi.org/10.3390/nu12103176 |
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author | Anderson, Sharon M. Thurman, Andrea R. Chandra, Neelima Jackson, Suzanne S. Asin, Susana Rollenhagen, Christiane Ghosh, Mimi Daniels, Jason Vann, Nikolas C. Clark, Meredith R. Doncel, Gustavo F. |
author_facet | Anderson, Sharon M. Thurman, Andrea R. Chandra, Neelima Jackson, Suzanne S. Asin, Susana Rollenhagen, Christiane Ghosh, Mimi Daniels, Jason Vann, Nikolas C. Clark, Meredith R. Doncel, Gustavo F. |
author_sort | Anderson, Sharon M. |
collection | PubMed |
description | While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels <62.5 nmol/L. Participants were randomized into either weekly or daily high-dose oral vitamin D supplementation groups. In addition to serum vitamin D levels, genital mucosal endpoints, including soluble mediators, immune cell populations, gene expression, and ex vivo HIV-1 infection, were assessed. While systemic vitamin D levels showed a significant increase following supplementation, these changes translated into modest effects on the cervicovaginal factors studied. Paradoxically, post-supplementation vitamin D levels were decreased in cervicovaginal fluids. Given the strong correlation between vitamin D status and HIV-1 infection and the widespread nature of vitamin D deficiency, further understanding of the role of vitamin D immunoregulation in the female reproductive tract is important. |
format | Online Article Text |
id | pubmed-7602985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76029852020-11-01 Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women Anderson, Sharon M. Thurman, Andrea R. Chandra, Neelima Jackson, Suzanne S. Asin, Susana Rollenhagen, Christiane Ghosh, Mimi Daniels, Jason Vann, Nikolas C. Clark, Meredith R. Doncel, Gustavo F. Nutrients Article While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels <62.5 nmol/L. Participants were randomized into either weekly or daily high-dose oral vitamin D supplementation groups. In addition to serum vitamin D levels, genital mucosal endpoints, including soluble mediators, immune cell populations, gene expression, and ex vivo HIV-1 infection, were assessed. While systemic vitamin D levels showed a significant increase following supplementation, these changes translated into modest effects on the cervicovaginal factors studied. Paradoxically, post-supplementation vitamin D levels were decreased in cervicovaginal fluids. Given the strong correlation between vitamin D status and HIV-1 infection and the widespread nature of vitamin D deficiency, further understanding of the role of vitamin D immunoregulation in the female reproductive tract is important. MDPI 2020-10-17 /pmc/articles/PMC7602985/ /pubmed/33080839 http://dx.doi.org/10.3390/nu12103176 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Anderson, Sharon M. Thurman, Andrea R. Chandra, Neelima Jackson, Suzanne S. Asin, Susana Rollenhagen, Christiane Ghosh, Mimi Daniels, Jason Vann, Nikolas C. Clark, Meredith R. Doncel, Gustavo F. Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women |
title | Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women |
title_full | Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women |
title_fullStr | Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women |
title_full_unstemmed | Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women |
title_short | Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women |
title_sort | vitamin d status impacts genital mucosal immunity and markers of hiv-1 susceptibility in women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602985/ https://www.ncbi.nlm.nih.gov/pubmed/33080839 http://dx.doi.org/10.3390/nu12103176 |
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