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Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia
The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the eff...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603028/ https://www.ncbi.nlm.nih.gov/pubmed/33081261 http://dx.doi.org/10.3390/brainsci10100742 |
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author | Madireddy, Samskruthi Madireddy, Sahithi |
author_facet | Madireddy, Samskruthi Madireddy, Sahithi |
author_sort | Madireddy, Samskruthi |
collection | PubMed |
description | The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the efficacy of the antioxidant defense mechanism, is believed to play a role in the pathophysiology of various brain disorders. One such disorder, schizophrenia, not only causes lifelong disability but also induces severe emotional distress; however, because of its onset in early adolescence or adulthood and its progressive development, consuming natural antioxidant products may help regulate the pathogenesis of schizophrenia. Therefore, elucidating the functions of ROS and dietary antioxidants in the pathogenesis of schizophrenia could help formulate improved therapeutic strategies for its prevention and treatment. This review focuses specifically on the roles of ROS and oxidative damage in the pathophysiology of schizophrenia, as well as the effects of nutrition, antipsychotic use, cognitive therapies, and quality of life on patients with schizophrenia. By improving our understanding of the effects of various nutrients on schizophrenia, it may become possible to develop nutritional strategies and supplements to treat the disorder, alleviate its symptoms, and facilitate long-term recovery. |
format | Online Article Text |
id | pubmed-7603028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76030282020-11-01 Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia Madireddy, Samskruthi Madireddy, Sahithi Brain Sci Review The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the efficacy of the antioxidant defense mechanism, is believed to play a role in the pathophysiology of various brain disorders. One such disorder, schizophrenia, not only causes lifelong disability but also induces severe emotional distress; however, because of its onset in early adolescence or adulthood and its progressive development, consuming natural antioxidant products may help regulate the pathogenesis of schizophrenia. Therefore, elucidating the functions of ROS and dietary antioxidants in the pathogenesis of schizophrenia could help formulate improved therapeutic strategies for its prevention and treatment. This review focuses specifically on the roles of ROS and oxidative damage in the pathophysiology of schizophrenia, as well as the effects of nutrition, antipsychotic use, cognitive therapies, and quality of life on patients with schizophrenia. By improving our understanding of the effects of various nutrients on schizophrenia, it may become possible to develop nutritional strategies and supplements to treat the disorder, alleviate its symptoms, and facilitate long-term recovery. MDPI 2020-10-16 /pmc/articles/PMC7603028/ /pubmed/33081261 http://dx.doi.org/10.3390/brainsci10100742 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Madireddy, Samskruthi Madireddy, Sahithi Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
title | Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
title_full | Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
title_fullStr | Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
title_full_unstemmed | Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
title_short | Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
title_sort | regulation of reactive oxygen species-mediated damage in the pathogenesis of schizophrenia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603028/ https://www.ncbi.nlm.nih.gov/pubmed/33081261 http://dx.doi.org/10.3390/brainsci10100742 |
work_keys_str_mv | AT madireddysamskruthi regulationofreactiveoxygenspeciesmediateddamageinthepathogenesisofschizophrenia AT madireddysahithi regulationofreactiveoxygenspeciesmediateddamageinthepathogenesisofschizophrenia |