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Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia

The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the eff...

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Detalles Bibliográficos
Autores principales: Madireddy, Samskruthi, Madireddy, Sahithi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603028/
https://www.ncbi.nlm.nih.gov/pubmed/33081261
http://dx.doi.org/10.3390/brainsci10100742
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author Madireddy, Samskruthi
Madireddy, Sahithi
author_facet Madireddy, Samskruthi
Madireddy, Sahithi
author_sort Madireddy, Samskruthi
collection PubMed
description The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the efficacy of the antioxidant defense mechanism, is believed to play a role in the pathophysiology of various brain disorders. One such disorder, schizophrenia, not only causes lifelong disability but also induces severe emotional distress; however, because of its onset in early adolescence or adulthood and its progressive development, consuming natural antioxidant products may help regulate the pathogenesis of schizophrenia. Therefore, elucidating the functions of ROS and dietary antioxidants in the pathogenesis of schizophrenia could help formulate improved therapeutic strategies for its prevention and treatment. This review focuses specifically on the roles of ROS and oxidative damage in the pathophysiology of schizophrenia, as well as the effects of nutrition, antipsychotic use, cognitive therapies, and quality of life on patients with schizophrenia. By improving our understanding of the effects of various nutrients on schizophrenia, it may become possible to develop nutritional strategies and supplements to treat the disorder, alleviate its symptoms, and facilitate long-term recovery.
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spelling pubmed-76030282020-11-01 Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia Madireddy, Samskruthi Madireddy, Sahithi Brain Sci Review The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the efficacy of the antioxidant defense mechanism, is believed to play a role in the pathophysiology of various brain disorders. One such disorder, schizophrenia, not only causes lifelong disability but also induces severe emotional distress; however, because of its onset in early adolescence or adulthood and its progressive development, consuming natural antioxidant products may help regulate the pathogenesis of schizophrenia. Therefore, elucidating the functions of ROS and dietary antioxidants in the pathogenesis of schizophrenia could help formulate improved therapeutic strategies for its prevention and treatment. This review focuses specifically on the roles of ROS and oxidative damage in the pathophysiology of schizophrenia, as well as the effects of nutrition, antipsychotic use, cognitive therapies, and quality of life on patients with schizophrenia. By improving our understanding of the effects of various nutrients on schizophrenia, it may become possible to develop nutritional strategies and supplements to treat the disorder, alleviate its symptoms, and facilitate long-term recovery. MDPI 2020-10-16 /pmc/articles/PMC7603028/ /pubmed/33081261 http://dx.doi.org/10.3390/brainsci10100742 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Madireddy, Samskruthi
Madireddy, Sahithi
Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia
title Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia
title_full Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia
title_fullStr Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia
title_full_unstemmed Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia
title_short Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia
title_sort regulation of reactive oxygen species-mediated damage in the pathogenesis of schizophrenia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603028/
https://www.ncbi.nlm.nih.gov/pubmed/33081261
http://dx.doi.org/10.3390/brainsci10100742
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