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Prevention of Neural Tube Defects by Folic Acid Supplementation: A National Population-Based Study

Folic acid supplementation is recommended for neural tube defect prevention during pregnancy. We conducted an observational, retrospective national registry study to determine the rate of dispensing of periconceptional folic acid after prescription in a sample of French women representative of the g...

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Autores principales: de la Fournière, Benoît, Dhombres, Ferdinand, Maurice, Paul, de Foucaud, Sabine, Lallemant, Pauline, Zérah, Michel, Guilbaud, Lucie, Jouannic, Jean-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603060/
https://www.ncbi.nlm.nih.gov/pubmed/33081287
http://dx.doi.org/10.3390/nu12103170
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author de la Fournière, Benoît
Dhombres, Ferdinand
Maurice, Paul
de Foucaud, Sabine
Lallemant, Pauline
Zérah, Michel
Guilbaud, Lucie
Jouannic, Jean-Marie
author_facet de la Fournière, Benoît
Dhombres, Ferdinand
Maurice, Paul
de Foucaud, Sabine
Lallemant, Pauline
Zérah, Michel
Guilbaud, Lucie
Jouannic, Jean-Marie
author_sort de la Fournière, Benoît
collection PubMed
description Folic acid supplementation is recommended for neural tube defect prevention during pregnancy. We conducted an observational, retrospective national registry study to determine the rate of dispensing of periconceptional folic acid after prescription in a sample of French women representative of the general population. Our study population (n = 186,061) was a representative sample of the French population, recorded in the Health Data System database on pharmacy dispensing of medication and mandatory reporting of pregnancy. Between 2006 and 2016, 14.3% of pregnant women had a prescription for folic acid supplementation during the month preceding conception and for the first 12 weeks of pregnancy. Of these prescriptions, 30.9% were issued before the start of pregnancy. This percentage was lower for first pregnancies. The rate of pharmacy dispensing during the preconception period increased progressively from 3.8% to 8.3% between 2006 and 2016. In France, the rate of pharmacy dispensing of periconceptional folic acid after medical prescription is very low and does not follow international recommendations. It seems essential to implement awareness-raising policies targeting the general population and physicians regarding effective periconceptional supplementation, particularly starting in the preconception period. Clarification of international recommendations and fortification of flour could improve the efficacy of folate supplementation at population level.
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spelling pubmed-76030602020-11-01 Prevention of Neural Tube Defects by Folic Acid Supplementation: A National Population-Based Study de la Fournière, Benoît Dhombres, Ferdinand Maurice, Paul de Foucaud, Sabine Lallemant, Pauline Zérah, Michel Guilbaud, Lucie Jouannic, Jean-Marie Nutrients Article Folic acid supplementation is recommended for neural tube defect prevention during pregnancy. We conducted an observational, retrospective national registry study to determine the rate of dispensing of periconceptional folic acid after prescription in a sample of French women representative of the general population. Our study population (n = 186,061) was a representative sample of the French population, recorded in the Health Data System database on pharmacy dispensing of medication and mandatory reporting of pregnancy. Between 2006 and 2016, 14.3% of pregnant women had a prescription for folic acid supplementation during the month preceding conception and for the first 12 weeks of pregnancy. Of these prescriptions, 30.9% were issued before the start of pregnancy. This percentage was lower for first pregnancies. The rate of pharmacy dispensing during the preconception period increased progressively from 3.8% to 8.3% between 2006 and 2016. In France, the rate of pharmacy dispensing of periconceptional folic acid after medical prescription is very low and does not follow international recommendations. It seems essential to implement awareness-raising policies targeting the general population and physicians regarding effective periconceptional supplementation, particularly starting in the preconception period. Clarification of international recommendations and fortification of flour could improve the efficacy of folate supplementation at population level. MDPI 2020-10-16 /pmc/articles/PMC7603060/ /pubmed/33081287 http://dx.doi.org/10.3390/nu12103170 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de la Fournière, Benoît
Dhombres, Ferdinand
Maurice, Paul
de Foucaud, Sabine
Lallemant, Pauline
Zérah, Michel
Guilbaud, Lucie
Jouannic, Jean-Marie
Prevention of Neural Tube Defects by Folic Acid Supplementation: A National Population-Based Study
title Prevention of Neural Tube Defects by Folic Acid Supplementation: A National Population-Based Study
title_full Prevention of Neural Tube Defects by Folic Acid Supplementation: A National Population-Based Study
title_fullStr Prevention of Neural Tube Defects by Folic Acid Supplementation: A National Population-Based Study
title_full_unstemmed Prevention of Neural Tube Defects by Folic Acid Supplementation: A National Population-Based Study
title_short Prevention of Neural Tube Defects by Folic Acid Supplementation: A National Population-Based Study
title_sort prevention of neural tube defects by folic acid supplementation: a national population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603060/
https://www.ncbi.nlm.nih.gov/pubmed/33081287
http://dx.doi.org/10.3390/nu12103170
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