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Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis
We present a retrospective of unique micro-fabrication problems and solutions that were encountered through over 10 years of retinal prosthesis product development, first for the Boston Retinal Implant Project initiated at the Massachusetts Institute of Technology and at Harvard Medical School’s tea...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603138/ https://www.ncbi.nlm.nih.gov/pubmed/33086504 http://dx.doi.org/10.3390/mi11100944 |
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author | Shire, Douglas B. Gingerich, Marcus D. Wong, Patricia I. Skvarla, Michael Cogan, Stuart F. Chen, Jinghua Wang, Wei Rizzo, Joseph F. |
author_facet | Shire, Douglas B. Gingerich, Marcus D. Wong, Patricia I. Skvarla, Michael Cogan, Stuart F. Chen, Jinghua Wang, Wei Rizzo, Joseph F. |
author_sort | Shire, Douglas B. |
collection | PubMed |
description | We present a retrospective of unique micro-fabrication problems and solutions that were encountered through over 10 years of retinal prosthesis product development, first for the Boston Retinal Implant Project initiated at the Massachusetts Institute of Technology and at Harvard Medical School’s teaching hospital, the Massachusetts Eye and Ear—and later at the startup company Bionic Eye Technologies, by some of the same personnel. These efforts culminated in the fabrication and assembly of 256+ channel visual prosthesis devices having flexible multi-electrode arrays that were successfully implanted sub-retinally in mini-pig animal models as part of our pre-clinical testing program. We report on the processing of the flexible multi-layered, planar and penetrating high-density electrode arrays, surgical tools for sub-retinal implantation, and other parts such as coil supports that facilitated the implantation of the peri-ocular device components. We begin with an overview of the implantable portion of our visual prosthesis system design, and describe in detail the micro-fabrication methods for creating the parts of our system that were assembled outside of our hermetically-sealed electronics package. We also note the unique surgical challenges that sub-retinal implantation of our micro-fabricated components presented, and how some of those issues were addressed through design, materials selection, and fabrication approaches. |
format | Online Article Text |
id | pubmed-7603138 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76031382020-11-01 Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis Shire, Douglas B. Gingerich, Marcus D. Wong, Patricia I. Skvarla, Michael Cogan, Stuart F. Chen, Jinghua Wang, Wei Rizzo, Joseph F. Micromachines (Basel) Article We present a retrospective of unique micro-fabrication problems and solutions that were encountered through over 10 years of retinal prosthesis product development, first for the Boston Retinal Implant Project initiated at the Massachusetts Institute of Technology and at Harvard Medical School’s teaching hospital, the Massachusetts Eye and Ear—and later at the startup company Bionic Eye Technologies, by some of the same personnel. These efforts culminated in the fabrication and assembly of 256+ channel visual prosthesis devices having flexible multi-electrode arrays that were successfully implanted sub-retinally in mini-pig animal models as part of our pre-clinical testing program. We report on the processing of the flexible multi-layered, planar and penetrating high-density electrode arrays, surgical tools for sub-retinal implantation, and other parts such as coil supports that facilitated the implantation of the peri-ocular device components. We begin with an overview of the implantable portion of our visual prosthesis system design, and describe in detail the micro-fabrication methods for creating the parts of our system that were assembled outside of our hermetically-sealed electronics package. We also note the unique surgical challenges that sub-retinal implantation of our micro-fabricated components presented, and how some of those issues were addressed through design, materials selection, and fabrication approaches. MDPI 2020-10-19 /pmc/articles/PMC7603138/ /pubmed/33086504 http://dx.doi.org/10.3390/mi11100944 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Shire, Douglas B. Gingerich, Marcus D. Wong, Patricia I. Skvarla, Michael Cogan, Stuart F. Chen, Jinghua Wang, Wei Rizzo, Joseph F. Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis |
title | Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis |
title_full | Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis |
title_fullStr | Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis |
title_full_unstemmed | Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis |
title_short | Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis |
title_sort | micro-fabrication of components for a high-density sub-retinal visual prosthesis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603138/ https://www.ncbi.nlm.nih.gov/pubmed/33086504 http://dx.doi.org/10.3390/mi11100944 |
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