Anti-biofilm Fe(3)O(4)@C(18)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings

The derivatives 5,7-dimethyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (1) and 7-methyl-5-phenyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (2) were fully characterized by single-crystal X-ray diffraction. Their supramolecular structure is built through both π–π stacking and C=S–π i...

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Autores principales: Olar, Rodica, Badea, Mihaela, Maxim, Cătălin, Grumezescu, Alexandru Mihai, Bleotu, Coralia, Măruţescu, Luminiţa, Chifiriuc, Mariana Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603173/
https://www.ncbi.nlm.nih.gov/pubmed/33080907
http://dx.doi.org/10.3390/ma13204640
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author Olar, Rodica
Badea, Mihaela
Maxim, Cătălin
Grumezescu, Alexandru Mihai
Bleotu, Coralia
Măruţescu, Luminiţa
Chifiriuc, Mariana Carmen
author_facet Olar, Rodica
Badea, Mihaela
Maxim, Cătălin
Grumezescu, Alexandru Mihai
Bleotu, Coralia
Măruţescu, Luminiţa
Chifiriuc, Mariana Carmen
author_sort Olar, Rodica
collection PubMed
description The derivatives 5,7-dimethyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (1) and 7-methyl-5-phenyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (2) were fully characterized by single-crystal X-ray diffraction. Their supramolecular structure is built through both π–π stacking and C=S–π interactions for both compounds. The embedment of the tested compounds into Fe(3)O(4)@C(18) core-shell nanocoatings increased the protection degree against Candida albicans biofilms on the catheter surface, suggesting that these bioactive nanocoatings could be further developed as non-cytotoxic strategies for fighting biofilm-associated fungal infections.
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spelling pubmed-76031732020-11-01 Anti-biofilm Fe(3)O(4)@C(18)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings Olar, Rodica Badea, Mihaela Maxim, Cătălin Grumezescu, Alexandru Mihai Bleotu, Coralia Măruţescu, Luminiţa Chifiriuc, Mariana Carmen Materials (Basel) Article The derivatives 5,7-dimethyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (1) and 7-methyl-5-phenyl[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate (2) were fully characterized by single-crystal X-ray diffraction. Their supramolecular structure is built through both π–π stacking and C=S–π interactions for both compounds. The embedment of the tested compounds into Fe(3)O(4)@C(18) core-shell nanocoatings increased the protection degree against Candida albicans biofilms on the catheter surface, suggesting that these bioactive nanocoatings could be further developed as non-cytotoxic strategies for fighting biofilm-associated fungal infections. MDPI 2020-10-17 /pmc/articles/PMC7603173/ /pubmed/33080907 http://dx.doi.org/10.3390/ma13204640 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Olar, Rodica
Badea, Mihaela
Maxim, Cătălin
Grumezescu, Alexandru Mihai
Bleotu, Coralia
Măruţescu, Luminiţa
Chifiriuc, Mariana Carmen
Anti-biofilm Fe(3)O(4)@C(18)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings
title Anti-biofilm Fe(3)O(4)@C(18)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings
title_full Anti-biofilm Fe(3)O(4)@C(18)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings
title_fullStr Anti-biofilm Fe(3)O(4)@C(18)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings
title_full_unstemmed Anti-biofilm Fe(3)O(4)@C(18)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings
title_short Anti-biofilm Fe(3)O(4)@C(18)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate Derivative Core-shell Nanocoatings
title_sort anti-biofilm fe(3)o(4)@c(18)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-4-ium-2-thiolate derivative core-shell nanocoatings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603173/
https://www.ncbi.nlm.nih.gov/pubmed/33080907
http://dx.doi.org/10.3390/ma13204640
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