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Who Is Afraid of CRP? Elevated Preoperative CRP Levels Might Attenuate the Increase in Inflammatory Parameters in Response to Lung Cancer Surgery

During surgery, ATP from damaged cells induces the release of interleukin-1β, a potent pro-inflammatory cytokine that contributes to the development of postoperative systemic inflammation, sepsis and multi-organ damage. We recently demonstrated that C-reactive protein (CRP) inhibits the ATP-induced...

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Autores principales: Meyer, Moritz Mecki, Brandenburg, Leon, Hudel, Helge, Agné, Alisa, Padberg, Winfried, Erdogan, Ali, Nef, Holger, Amati, Anca-Laura, Dörr, Oliver, Witte, Biruta, Grau, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603240/
https://www.ncbi.nlm.nih.gov/pubmed/33080990
http://dx.doi.org/10.3390/jcm9103340
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author Meyer, Moritz Mecki
Brandenburg, Leon
Hudel, Helge
Agné, Alisa
Padberg, Winfried
Erdogan, Ali
Nef, Holger
Amati, Anca-Laura
Dörr, Oliver
Witte, Biruta
Grau, Veronika
author_facet Meyer, Moritz Mecki
Brandenburg, Leon
Hudel, Helge
Agné, Alisa
Padberg, Winfried
Erdogan, Ali
Nef, Holger
Amati, Anca-Laura
Dörr, Oliver
Witte, Biruta
Grau, Veronika
author_sort Meyer, Moritz Mecki
collection PubMed
description During surgery, ATP from damaged cells induces the release of interleukin-1β, a potent pro-inflammatory cytokine that contributes to the development of postoperative systemic inflammation, sepsis and multi-organ damage. We recently demonstrated that C-reactive protein (CRP) inhibits the ATP-induced release of monocytic interleukin-1β, although high CRP levels are deemed to be a poor prognostic marker. Here, we retrospectively investigated if preoperative CRP levels correlate with postoperative CRP, leukocyte counts and fever in the context of anatomical lung resection and systematic lymph node dissection as first line lung cancer therapy. No correlation was found in the overall results. In men, however, preoperative CRP and leukocyte counts positively correlated on postoperative days one to two, and a negative correlation of CRP and fever was seen in women. These correlations were more pronounced in men taking statins and in statin-naïve women. Accordingly, the inhibitory effect of CRP on the ATP-induced interleukin-1β release was blunted in monocytes from coronary heart disease patients treated with atorvastatin compared to monocytes obtained before medication. Hence, the common notion that elevated CRP levels predict more severe postoperative inflammation should be questioned. We rather hypothesize that in women and statin-naïve patients, high CRP levels attenuate trauma-induced increases in inflammatory markers.
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spelling pubmed-76032402020-11-01 Who Is Afraid of CRP? Elevated Preoperative CRP Levels Might Attenuate the Increase in Inflammatory Parameters in Response to Lung Cancer Surgery Meyer, Moritz Mecki Brandenburg, Leon Hudel, Helge Agné, Alisa Padberg, Winfried Erdogan, Ali Nef, Holger Amati, Anca-Laura Dörr, Oliver Witte, Biruta Grau, Veronika J Clin Med Article During surgery, ATP from damaged cells induces the release of interleukin-1β, a potent pro-inflammatory cytokine that contributes to the development of postoperative systemic inflammation, sepsis and multi-organ damage. We recently demonstrated that C-reactive protein (CRP) inhibits the ATP-induced release of monocytic interleukin-1β, although high CRP levels are deemed to be a poor prognostic marker. Here, we retrospectively investigated if preoperative CRP levels correlate with postoperative CRP, leukocyte counts and fever in the context of anatomical lung resection and systematic lymph node dissection as first line lung cancer therapy. No correlation was found in the overall results. In men, however, preoperative CRP and leukocyte counts positively correlated on postoperative days one to two, and a negative correlation of CRP and fever was seen in women. These correlations were more pronounced in men taking statins and in statin-naïve women. Accordingly, the inhibitory effect of CRP on the ATP-induced interleukin-1β release was blunted in monocytes from coronary heart disease patients treated with atorvastatin compared to monocytes obtained before medication. Hence, the common notion that elevated CRP levels predict more severe postoperative inflammation should be questioned. We rather hypothesize that in women and statin-naïve patients, high CRP levels attenuate trauma-induced increases in inflammatory markers. MDPI 2020-10-18 /pmc/articles/PMC7603240/ /pubmed/33080990 http://dx.doi.org/10.3390/jcm9103340 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meyer, Moritz Mecki
Brandenburg, Leon
Hudel, Helge
Agné, Alisa
Padberg, Winfried
Erdogan, Ali
Nef, Holger
Amati, Anca-Laura
Dörr, Oliver
Witte, Biruta
Grau, Veronika
Who Is Afraid of CRP? Elevated Preoperative CRP Levels Might Attenuate the Increase in Inflammatory Parameters in Response to Lung Cancer Surgery
title Who Is Afraid of CRP? Elevated Preoperative CRP Levels Might Attenuate the Increase in Inflammatory Parameters in Response to Lung Cancer Surgery
title_full Who Is Afraid of CRP? Elevated Preoperative CRP Levels Might Attenuate the Increase in Inflammatory Parameters in Response to Lung Cancer Surgery
title_fullStr Who Is Afraid of CRP? Elevated Preoperative CRP Levels Might Attenuate the Increase in Inflammatory Parameters in Response to Lung Cancer Surgery
title_full_unstemmed Who Is Afraid of CRP? Elevated Preoperative CRP Levels Might Attenuate the Increase in Inflammatory Parameters in Response to Lung Cancer Surgery
title_short Who Is Afraid of CRP? Elevated Preoperative CRP Levels Might Attenuate the Increase in Inflammatory Parameters in Response to Lung Cancer Surgery
title_sort who is afraid of crp? elevated preoperative crp levels might attenuate the increase in inflammatory parameters in response to lung cancer surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603240/
https://www.ncbi.nlm.nih.gov/pubmed/33080990
http://dx.doi.org/10.3390/jcm9103340
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