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Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement

Background: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. Objective: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without...

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Autores principales: De Palma, Luca, Pepi, Chiara, De Benedictis, Alessandro, Pietrafusa, Nicola, Mastronuzzi, Angela, Cacchione, Antonella, Carfì-Pavia, Giusy, Rossi-Espagnet, Camilla, Diomedi-Camassei, Francesca, Rossi, Sabrina, Napolitano, Antonio, Carai, Andrea, Colafati, Giovanna Stefania, Longo, Daniela, Curatolo, Paolo, Vigevano, Federico, Marras, Carlo Efisio, Specchio, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603244/
https://www.ncbi.nlm.nih.gov/pubmed/33081051
http://dx.doi.org/10.3390/brainsci10100752
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author De Palma, Luca
Pepi, Chiara
De Benedictis, Alessandro
Pietrafusa, Nicola
Mastronuzzi, Angela
Cacchione, Antonella
Carfì-Pavia, Giusy
Rossi-Espagnet, Camilla
Diomedi-Camassei, Francesca
Rossi, Sabrina
Napolitano, Antonio
Carai, Andrea
Colafati, Giovanna Stefania
Longo, Daniela
Curatolo, Paolo
Vigevano, Federico
Marras, Carlo Efisio
Specchio, Nicola
author_facet De Palma, Luca
Pepi, Chiara
De Benedictis, Alessandro
Pietrafusa, Nicola
Mastronuzzi, Angela
Cacchione, Antonella
Carfì-Pavia, Giusy
Rossi-Espagnet, Camilla
Diomedi-Camassei, Francesca
Rossi, Sabrina
Napolitano, Antonio
Carai, Andrea
Colafati, Giovanna Stefania
Longo, Daniela
Curatolo, Paolo
Vigevano, Federico
Marras, Carlo Efisio
Specchio, Nicola
author_sort De Palma, Luca
collection PubMed
description Background: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. Objective: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without MI within our cohort of pediatric patients with LEATs. Methods: We retrospectively reviewed all pediatric patients (<18 y) who underwent epilepsy surgery between 2011 and 2017 at our hospital. Cohort inclusion required histological diagnosis of LEATs and post-surgical follow-up of ≥2 y. We subsequently stratified patients according to presence of neuroradiological MI. Results: We identified 37 patients: five with MI and 32 without. Half of patients (19) were drug sensitive at surgery; similar between groups. The group with MI differed mainly for age of epilepsy-onset (0.6 vs. 7.0 y) but not for epilepsy duration (0.9 vs. 1.5 y). Post-surgery radiological follow-up (median 4.0 y; IQR 2.8–5.0 y) did not indicate disease progression. Seizure outcome was excellent in both groups, with 34 patients overall being both drug- and seizure-free. Conclusions: Our study identified a new subgroup of LEATs with focal MI and excellent post-surgical outcome. Moreover, this highlights the effectiveness of early surgery in pediatric LEATs.
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spelling pubmed-76032442020-11-01 Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement De Palma, Luca Pepi, Chiara De Benedictis, Alessandro Pietrafusa, Nicola Mastronuzzi, Angela Cacchione, Antonella Carfì-Pavia, Giusy Rossi-Espagnet, Camilla Diomedi-Camassei, Francesca Rossi, Sabrina Napolitano, Antonio Carai, Andrea Colafati, Giovanna Stefania Longo, Daniela Curatolo, Paolo Vigevano, Federico Marras, Carlo Efisio Specchio, Nicola Brain Sci Article Background: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. Objective: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without MI within our cohort of pediatric patients with LEATs. Methods: We retrospectively reviewed all pediatric patients (<18 y) who underwent epilepsy surgery between 2011 and 2017 at our hospital. Cohort inclusion required histological diagnosis of LEATs and post-surgical follow-up of ≥2 y. We subsequently stratified patients according to presence of neuroradiological MI. Results: We identified 37 patients: five with MI and 32 without. Half of patients (19) were drug sensitive at surgery; similar between groups. The group with MI differed mainly for age of epilepsy-onset (0.6 vs. 7.0 y) but not for epilepsy duration (0.9 vs. 1.5 y). Post-surgery radiological follow-up (median 4.0 y; IQR 2.8–5.0 y) did not indicate disease progression. Seizure outcome was excellent in both groups, with 34 patients overall being both drug- and seizure-free. Conclusions: Our study identified a new subgroup of LEATs with focal MI and excellent post-surgical outcome. Moreover, this highlights the effectiveness of early surgery in pediatric LEATs. MDPI 2020-10-18 /pmc/articles/PMC7603244/ /pubmed/33081051 http://dx.doi.org/10.3390/brainsci10100752 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
De Palma, Luca
Pepi, Chiara
De Benedictis, Alessandro
Pietrafusa, Nicola
Mastronuzzi, Angela
Cacchione, Antonella
Carfì-Pavia, Giusy
Rossi-Espagnet, Camilla
Diomedi-Camassei, Francesca
Rossi, Sabrina
Napolitano, Antonio
Carai, Andrea
Colafati, Giovanna Stefania
Longo, Daniela
Curatolo, Paolo
Vigevano, Federico
Marras, Carlo Efisio
Specchio, Nicola
Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement
title Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement
title_full Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement
title_fullStr Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement
title_full_unstemmed Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement
title_short Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement
title_sort early onset epilepsy caused by low-grade epilepsy-associated tumors and focal meningeal involvement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603244/
https://www.ncbi.nlm.nih.gov/pubmed/33081051
http://dx.doi.org/10.3390/brainsci10100752
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