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Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement
Background: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. Objective: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603244/ https://www.ncbi.nlm.nih.gov/pubmed/33081051 http://dx.doi.org/10.3390/brainsci10100752 |
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author | De Palma, Luca Pepi, Chiara De Benedictis, Alessandro Pietrafusa, Nicola Mastronuzzi, Angela Cacchione, Antonella Carfì-Pavia, Giusy Rossi-Espagnet, Camilla Diomedi-Camassei, Francesca Rossi, Sabrina Napolitano, Antonio Carai, Andrea Colafati, Giovanna Stefania Longo, Daniela Curatolo, Paolo Vigevano, Federico Marras, Carlo Efisio Specchio, Nicola |
author_facet | De Palma, Luca Pepi, Chiara De Benedictis, Alessandro Pietrafusa, Nicola Mastronuzzi, Angela Cacchione, Antonella Carfì-Pavia, Giusy Rossi-Espagnet, Camilla Diomedi-Camassei, Francesca Rossi, Sabrina Napolitano, Antonio Carai, Andrea Colafati, Giovanna Stefania Longo, Daniela Curatolo, Paolo Vigevano, Federico Marras, Carlo Efisio Specchio, Nicola |
author_sort | De Palma, Luca |
collection | PubMed |
description | Background: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. Objective: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without MI within our cohort of pediatric patients with LEATs. Methods: We retrospectively reviewed all pediatric patients (<18 y) who underwent epilepsy surgery between 2011 and 2017 at our hospital. Cohort inclusion required histological diagnosis of LEATs and post-surgical follow-up of ≥2 y. We subsequently stratified patients according to presence of neuroradiological MI. Results: We identified 37 patients: five with MI and 32 without. Half of patients (19) were drug sensitive at surgery; similar between groups. The group with MI differed mainly for age of epilepsy-onset (0.6 vs. 7.0 y) but not for epilepsy duration (0.9 vs. 1.5 y). Post-surgery radiological follow-up (median 4.0 y; IQR 2.8–5.0 y) did not indicate disease progression. Seizure outcome was excellent in both groups, with 34 patients overall being both drug- and seizure-free. Conclusions: Our study identified a new subgroup of LEATs with focal MI and excellent post-surgical outcome. Moreover, this highlights the effectiveness of early surgery in pediatric LEATs. |
format | Online Article Text |
id | pubmed-7603244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76032442020-11-01 Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement De Palma, Luca Pepi, Chiara De Benedictis, Alessandro Pietrafusa, Nicola Mastronuzzi, Angela Cacchione, Antonella Carfì-Pavia, Giusy Rossi-Espagnet, Camilla Diomedi-Camassei, Francesca Rossi, Sabrina Napolitano, Antonio Carai, Andrea Colafati, Giovanna Stefania Longo, Daniela Curatolo, Paolo Vigevano, Federico Marras, Carlo Efisio Specchio, Nicola Brain Sci Article Background: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. Objective: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without MI within our cohort of pediatric patients with LEATs. Methods: We retrospectively reviewed all pediatric patients (<18 y) who underwent epilepsy surgery between 2011 and 2017 at our hospital. Cohort inclusion required histological diagnosis of LEATs and post-surgical follow-up of ≥2 y. We subsequently stratified patients according to presence of neuroradiological MI. Results: We identified 37 patients: five with MI and 32 without. Half of patients (19) were drug sensitive at surgery; similar between groups. The group with MI differed mainly for age of epilepsy-onset (0.6 vs. 7.0 y) but not for epilepsy duration (0.9 vs. 1.5 y). Post-surgery radiological follow-up (median 4.0 y; IQR 2.8–5.0 y) did not indicate disease progression. Seizure outcome was excellent in both groups, with 34 patients overall being both drug- and seizure-free. Conclusions: Our study identified a new subgroup of LEATs with focal MI and excellent post-surgical outcome. Moreover, this highlights the effectiveness of early surgery in pediatric LEATs. MDPI 2020-10-18 /pmc/articles/PMC7603244/ /pubmed/33081051 http://dx.doi.org/10.3390/brainsci10100752 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article De Palma, Luca Pepi, Chiara De Benedictis, Alessandro Pietrafusa, Nicola Mastronuzzi, Angela Cacchione, Antonella Carfì-Pavia, Giusy Rossi-Espagnet, Camilla Diomedi-Camassei, Francesca Rossi, Sabrina Napolitano, Antonio Carai, Andrea Colafati, Giovanna Stefania Longo, Daniela Curatolo, Paolo Vigevano, Federico Marras, Carlo Efisio Specchio, Nicola Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
title | Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
title_full | Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
title_fullStr | Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
title_full_unstemmed | Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
title_short | Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
title_sort | early onset epilepsy caused by low-grade epilepsy-associated tumors and focal meningeal involvement |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603244/ https://www.ncbi.nlm.nih.gov/pubmed/33081051 http://dx.doi.org/10.3390/brainsci10100752 |
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