Chemicals orchestrate reprogramming with hierarchical activation of master transcription factors primed by endogenous Sox17 activation

Mouse somatic cells can be chemically reprogrammed into pluripotent stem cells (CiPSCs) through an intermediate extraembryonic endoderm (XEN)-like state. However, it is elusive how the chemicals orchestrate the cell fate alteration. In this study, we analyze molecular dynamics in chemical reprogramm...

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Detalles Bibliográficos
Autores principales: Yang, Zhenghao, Xu, Xiaochan, Gu, Chan, Li, Jun, Wu, Qihong, Ye, Can, Nielsen, Alexander Valentin, Mao, Lichao, Ye, Junqing, Bai, Ke, Guo, Fan, Tang, Chao, Zhao, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603307/
https://www.ncbi.nlm.nih.gov/pubmed/33128002
http://dx.doi.org/10.1038/s42003-020-01346-w

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