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The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation
Human glioblastoma (GBM) is the most common primary malignant brain tumor. A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem cell-like properties, their high resistance to conventional treatments and the...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603339/ https://www.ncbi.nlm.nih.gov/pubmed/33128011 http://dx.doi.org/10.1038/s41598-020-75300-5 |
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author | Gauthier, Laurent R. Saati, Mahasen Bensalah-Pigeon, Hayet Ben M’Barek, Karim Gitton-Quent, Oscar Bertrand, Romane Busso, Didier Mouthon, Marc-André Collura, Ada Junier, Marie-Pierre Chneiweiss, Hervé Pineda, José R. Boussin, François D. |
author_facet | Gauthier, Laurent R. Saati, Mahasen Bensalah-Pigeon, Hayet Ben M’Barek, Karim Gitton-Quent, Oscar Bertrand, Romane Busso, Didier Mouthon, Marc-André Collura, Ada Junier, Marie-Pierre Chneiweiss, Hervé Pineda, José R. Boussin, François D. |
author_sort | Gauthier, Laurent R. |
collection | PubMed |
description | Human glioblastoma (GBM) is the most common primary malignant brain tumor. A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem cell-like properties, their high resistance to conventional treatments and their high invasion capacity. We show that ionizing radiation specifically enhances the motility and invasiveness of human GSCs through the stabilization and nuclear accumulation of the hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activates the Junction-mediating and regulatory protein (JMY). Finally, JMY accumulates in the cytoplasm where it stimulates GSC migration via its actin nucleation-promoting activity. Targeting JMY could thus open the way to the development of new therapeutic strategies to improve the efficacy of radiotherapy and prevent glioma recurrence. |
format | Online Article Text |
id | pubmed-7603339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76033392020-11-03 The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation Gauthier, Laurent R. Saati, Mahasen Bensalah-Pigeon, Hayet Ben M’Barek, Karim Gitton-Quent, Oscar Bertrand, Romane Busso, Didier Mouthon, Marc-André Collura, Ada Junier, Marie-Pierre Chneiweiss, Hervé Pineda, José R. Boussin, François D. Sci Rep Article Human glioblastoma (GBM) is the most common primary malignant brain tumor. A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem cell-like properties, their high resistance to conventional treatments and their high invasion capacity. We show that ionizing radiation specifically enhances the motility and invasiveness of human GSCs through the stabilization and nuclear accumulation of the hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activates the Junction-mediating and regulatory protein (JMY). Finally, JMY accumulates in the cytoplasm where it stimulates GSC migration via its actin nucleation-promoting activity. Targeting JMY could thus open the way to the development of new therapeutic strategies to improve the efficacy of radiotherapy and prevent glioma recurrence. Nature Publishing Group UK 2020-10-30 /pmc/articles/PMC7603339/ /pubmed/33128011 http://dx.doi.org/10.1038/s41598-020-75300-5 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Gauthier, Laurent R. Saati, Mahasen Bensalah-Pigeon, Hayet Ben M’Barek, Karim Gitton-Quent, Oscar Bertrand, Romane Busso, Didier Mouthon, Marc-André Collura, Ada Junier, Marie-Pierre Chneiweiss, Hervé Pineda, José R. Boussin, François D. The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation |
title | The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation |
title_full | The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation |
title_fullStr | The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation |
title_full_unstemmed | The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation |
title_short | The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation |
title_sort | hif1α/jmy pathway promotes glioblastoma stem-like cell invasiveness after irradiation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603339/ https://www.ncbi.nlm.nih.gov/pubmed/33128011 http://dx.doi.org/10.1038/s41598-020-75300-5 |
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