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Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study
Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603368/ https://www.ncbi.nlm.nih.gov/pubmed/33086652 http://dx.doi.org/10.3390/nu12103196 |
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author | Voltas, Núria Canals, Josefa Hernández-Martínez, Carmen Serrat, Núria Basora, Josep Arija, Victoria |
author_facet | Voltas, Núria Canals, Josefa Hernández-Martínez, Carmen Serrat, Núria Basora, Josep Arija, Victoria |
author_sort | Voltas, Núria |
collection | PubMed |
description | Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother–infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded. Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (<30 nmol/L) predicted a worse performance in cognitive and language skills. Language performance worsened with lower vitamin D levels (<20 nmol/L). In the third trimester, this highly deficient level was also associated with lower motor skills. Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment. |
format | Online Article Text |
id | pubmed-7603368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76033682020-11-01 Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study Voltas, Núria Canals, Josefa Hernández-Martínez, Carmen Serrat, Núria Basora, Josep Arija, Victoria Nutrients Article Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother–infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded. Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (<30 nmol/L) predicted a worse performance in cognitive and language skills. Language performance worsened with lower vitamin D levels (<20 nmol/L). In the third trimester, this highly deficient level was also associated with lower motor skills. Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment. MDPI 2020-10-19 /pmc/articles/PMC7603368/ /pubmed/33086652 http://dx.doi.org/10.3390/nu12103196 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Voltas, Núria Canals, Josefa Hernández-Martínez, Carmen Serrat, Núria Basora, Josep Arija, Victoria Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
title | Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
title_full | Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
title_fullStr | Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
title_full_unstemmed | Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
title_short | Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study |
title_sort | effect of vitamin d status during pregnancy on infant neurodevelopment: the eclipses study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603368/ https://www.ncbi.nlm.nih.gov/pubmed/33086652 http://dx.doi.org/10.3390/nu12103196 |
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