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Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study

Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women...

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Autores principales: Voltas, Núria, Canals, Josefa, Hernández-Martínez, Carmen, Serrat, Núria, Basora, Josep, Arija, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603368/
https://www.ncbi.nlm.nih.gov/pubmed/33086652
http://dx.doi.org/10.3390/nu12103196
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author Voltas, Núria
Canals, Josefa
Hernández-Martínez, Carmen
Serrat, Núria
Basora, Josep
Arija, Victoria
author_facet Voltas, Núria
Canals, Josefa
Hernández-Martínez, Carmen
Serrat, Núria
Basora, Josep
Arija, Victoria
author_sort Voltas, Núria
collection PubMed
description Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother–infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded. Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (<30 nmol/L) predicted a worse performance in cognitive and language skills. Language performance worsened with lower vitamin D levels (<20 nmol/L). In the third trimester, this highly deficient level was also associated with lower motor skills. Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment.
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spelling pubmed-76033682020-11-01 Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study Voltas, Núria Canals, Josefa Hernández-Martínez, Carmen Serrat, Núria Basora, Josep Arija, Victoria Nutrients Article Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother–infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded. Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (<30 nmol/L) predicted a worse performance in cognitive and language skills. Language performance worsened with lower vitamin D levels (<20 nmol/L). In the third trimester, this highly deficient level was also associated with lower motor skills. Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment. MDPI 2020-10-19 /pmc/articles/PMC7603368/ /pubmed/33086652 http://dx.doi.org/10.3390/nu12103196 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Voltas, Núria
Canals, Josefa
Hernández-Martínez, Carmen
Serrat, Núria
Basora, Josep
Arija, Victoria
Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study
title Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study
title_full Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study
title_fullStr Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study
title_full_unstemmed Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study
title_short Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study
title_sort effect of vitamin d status during pregnancy on infant neurodevelopment: the eclipses study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603368/
https://www.ncbi.nlm.nih.gov/pubmed/33086652
http://dx.doi.org/10.3390/nu12103196
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