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Localization of epileptic seizure focus by computerized analysis of fMRI recordings
By computerized analysis of cortical activity recorded via fMRI for pediatric epilepsy patients, we implement algorithmic localization of epileptic seizure focus within one of eight cortical lobes. Our innovative machine learning techniques involve intensive analysis of large matrices of mutual info...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603444/ https://www.ncbi.nlm.nih.gov/pubmed/33128629 http://dx.doi.org/10.1186/s40708-020-00114-0 |
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author | Hekmati, Rasoul Azencott, Robert Zhang, Wei Chu, Zili D. Paldino, Michael J. |
author_facet | Hekmati, Rasoul Azencott, Robert Zhang, Wei Chu, Zili D. Paldino, Michael J. |
author_sort | Hekmati, Rasoul |
collection | PubMed |
description | By computerized analysis of cortical activity recorded via fMRI for pediatric epilepsy patients, we implement algorithmic localization of epileptic seizure focus within one of eight cortical lobes. Our innovative machine learning techniques involve intensive analysis of large matrices of mutual information coefficients between pairs of anatomically identified cortical regions. Drastic selection of pairs of regions with biologically significant inter-connectivity provides efficient inputs for our multi-layer perceptron (MLP) classifier. By imposing rigorous parameter parsimony to avoid overfitting, we construct a small-size MLP with very good percentages of successful classification. |
format | Online Article Text |
id | pubmed-7603444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-76034442020-11-02 Localization of epileptic seizure focus by computerized analysis of fMRI recordings Hekmati, Rasoul Azencott, Robert Zhang, Wei Chu, Zili D. Paldino, Michael J. Brain Inform Research By computerized analysis of cortical activity recorded via fMRI for pediatric epilepsy patients, we implement algorithmic localization of epileptic seizure focus within one of eight cortical lobes. Our innovative machine learning techniques involve intensive analysis of large matrices of mutual information coefficients between pairs of anatomically identified cortical regions. Drastic selection of pairs of regions with biologically significant inter-connectivity provides efficient inputs for our multi-layer perceptron (MLP) classifier. By imposing rigorous parameter parsimony to avoid overfitting, we construct a small-size MLP with very good percentages of successful classification. Springer Berlin Heidelberg 2020-10-31 /pmc/articles/PMC7603444/ /pubmed/33128629 http://dx.doi.org/10.1186/s40708-020-00114-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Hekmati, Rasoul Azencott, Robert Zhang, Wei Chu, Zili D. Paldino, Michael J. Localization of epileptic seizure focus by computerized analysis of fMRI recordings |
title | Localization of epileptic seizure focus by computerized analysis of fMRI recordings |
title_full | Localization of epileptic seizure focus by computerized analysis of fMRI recordings |
title_fullStr | Localization of epileptic seizure focus by computerized analysis of fMRI recordings |
title_full_unstemmed | Localization of epileptic seizure focus by computerized analysis of fMRI recordings |
title_short | Localization of epileptic seizure focus by computerized analysis of fMRI recordings |
title_sort | localization of epileptic seizure focus by computerized analysis of fmri recordings |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603444/ https://www.ncbi.nlm.nih.gov/pubmed/33128629 http://dx.doi.org/10.1186/s40708-020-00114-0 |
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