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An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer

PURPOSE: Colorectal cancer is one of the most common malignant primary tumors, prone to metastasis, and associated with a poor prognosis. As autophagy is closely related to the development and treatment of colorectal cancer, we investigated the potential prognostic value of long noncoding RNA (lncRN...

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Autores principales: Wei, Jingsun, Ge, Xiaoxu, Tang, Yang, Qian, Yucheng, Lu, Wei, Jiang, Kai, Fang, Yimin, Hwang, Maxwell, Fu, Dongliang, Xiao, Qian, Ding, Kefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603611/
https://www.ncbi.nlm.nih.gov/pubmed/33149738
http://dx.doi.org/10.1155/2020/4728947
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author Wei, Jingsun
Ge, Xiaoxu
Tang, Yang
Qian, Yucheng
Lu, Wei
Jiang, Kai
Fang, Yimin
Hwang, Maxwell
Fu, Dongliang
Xiao, Qian
Ding, Kefeng
author_facet Wei, Jingsun
Ge, Xiaoxu
Tang, Yang
Qian, Yucheng
Lu, Wei
Jiang, Kai
Fang, Yimin
Hwang, Maxwell
Fu, Dongliang
Xiao, Qian
Ding, Kefeng
author_sort Wei, Jingsun
collection PubMed
description PURPOSE: Colorectal cancer is one of the most common malignant primary tumors, prone to metastasis, and associated with a poor prognosis. As autophagy is closely related to the development and treatment of colorectal cancer, we investigated the potential prognostic value of long noncoding RNA (lncRNA) associated with autophagy in colorectal cancer. METHODS: In this study, we acquired information on the expression of lncRNAs in colorectal cancer from the Cancer Genome Atlas (TCGA) database and found that 860 lncRNAs were associated with autophagy-related genes. Subsequently, univariate Cox regression analysis was used to investigate 32 autophagy-related lncRNAs linked to colon cancer prognosis. Subsequently, eight of the 32 autophagy-related lncRNAs (i.e., long intergenic nonprotein coding RNA 1503 [LINC01503], ZEB1 antisense RNA 1 [ZEB1-AS1], AC087481.3, AC008760.1, AC073896.3, AL138756.1, AL022323.1, and TNFRSF10A-AS1) were selected through multivariate Cox regression analysis. Based on these autophagy-related lncRNAs, a risk signature was constructed, and the patients were divided into high- and low-risk groups. RESULTS: The high-risk group's overall survival time was significantly shorter than that of the low-risk group (p < 0.0001). Receiver operating characteristic curve analysis was performed to further confirm the validity of the model (area under the curve: 0.689). Moreover, multivariate regression suggested that the risk score was a significant prognostic risk factor in colorectal cancer. Gene set enrichment analysis showed that these gene sets are significantly enriched in cancer-related pathways, such as Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling. CONCLUSION: The risk signature of eight autophagy-related lncRNAs has prognostic potential for colorectal cancer. These autophagy-related lncRNAs may play a vital role in the biology of colorectal cancer.
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spelling pubmed-76036112020-11-03 An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer Wei, Jingsun Ge, Xiaoxu Tang, Yang Qian, Yucheng Lu, Wei Jiang, Kai Fang, Yimin Hwang, Maxwell Fu, Dongliang Xiao, Qian Ding, Kefeng J Oncol Research Article PURPOSE: Colorectal cancer is one of the most common malignant primary tumors, prone to metastasis, and associated with a poor prognosis. As autophagy is closely related to the development and treatment of colorectal cancer, we investigated the potential prognostic value of long noncoding RNA (lncRNA) associated with autophagy in colorectal cancer. METHODS: In this study, we acquired information on the expression of lncRNAs in colorectal cancer from the Cancer Genome Atlas (TCGA) database and found that 860 lncRNAs were associated with autophagy-related genes. Subsequently, univariate Cox regression analysis was used to investigate 32 autophagy-related lncRNAs linked to colon cancer prognosis. Subsequently, eight of the 32 autophagy-related lncRNAs (i.e., long intergenic nonprotein coding RNA 1503 [LINC01503], ZEB1 antisense RNA 1 [ZEB1-AS1], AC087481.3, AC008760.1, AC073896.3, AL138756.1, AL022323.1, and TNFRSF10A-AS1) were selected through multivariate Cox regression analysis. Based on these autophagy-related lncRNAs, a risk signature was constructed, and the patients were divided into high- and low-risk groups. RESULTS: The high-risk group's overall survival time was significantly shorter than that of the low-risk group (p < 0.0001). Receiver operating characteristic curve analysis was performed to further confirm the validity of the model (area under the curve: 0.689). Moreover, multivariate regression suggested that the risk score was a significant prognostic risk factor in colorectal cancer. Gene set enrichment analysis showed that these gene sets are significantly enriched in cancer-related pathways, such as Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling. CONCLUSION: The risk signature of eight autophagy-related lncRNAs has prognostic potential for colorectal cancer. These autophagy-related lncRNAs may play a vital role in the biology of colorectal cancer. Hindawi 2020-10-21 /pmc/articles/PMC7603611/ /pubmed/33149738 http://dx.doi.org/10.1155/2020/4728947 Text en Copyright © 2020 Jingsun Wei et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wei, Jingsun
Ge, Xiaoxu
Tang, Yang
Qian, Yucheng
Lu, Wei
Jiang, Kai
Fang, Yimin
Hwang, Maxwell
Fu, Dongliang
Xiao, Qian
Ding, Kefeng
An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer
title An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer
title_full An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer
title_fullStr An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer
title_full_unstemmed An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer
title_short An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer
title_sort autophagy-related long noncoding rna signature contributes to poor prognosis in colorectal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603611/
https://www.ncbi.nlm.nih.gov/pubmed/33149738
http://dx.doi.org/10.1155/2020/4728947
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