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Epigenetic Regulation of Dental Pulp Stem Cell Fate
Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipot...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603635/ https://www.ncbi.nlm.nih.gov/pubmed/33149742 http://dx.doi.org/10.1155/2020/8876265 |
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author | Zhou, Dan Gan, Lu Peng, Yiran Zhou, Yachuan Zhou, Xin Wan, Mian Fan, Yi Xu, Xin Zhou, Xuedong Zheng, Liwei Du, Wei |
author_facet | Zhou, Dan Gan, Lu Peng, Yiran Zhou, Yachuan Zhou, Xin Wan, Mian Fan, Yi Xu, Xin Zhou, Xuedong Zheng, Liwei Du, Wei |
author_sort | Zhou, Dan |
collection | PubMed |
description | Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs. |
format | Online Article Text |
id | pubmed-7603635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-76036352020-11-03 Epigenetic Regulation of Dental Pulp Stem Cell Fate Zhou, Dan Gan, Lu Peng, Yiran Zhou, Yachuan Zhou, Xin Wan, Mian Fan, Yi Xu, Xin Zhou, Xuedong Zheng, Liwei Du, Wei Stem Cells Int Review Article Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs. Hindawi 2020-10-13 /pmc/articles/PMC7603635/ /pubmed/33149742 http://dx.doi.org/10.1155/2020/8876265 Text en Copyright © 2020 Dan Zhou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhou, Dan Gan, Lu Peng, Yiran Zhou, Yachuan Zhou, Xin Wan, Mian Fan, Yi Xu, Xin Zhou, Xuedong Zheng, Liwei Du, Wei Epigenetic Regulation of Dental Pulp Stem Cell Fate |
title | Epigenetic Regulation of Dental Pulp Stem Cell Fate |
title_full | Epigenetic Regulation of Dental Pulp Stem Cell Fate |
title_fullStr | Epigenetic Regulation of Dental Pulp Stem Cell Fate |
title_full_unstemmed | Epigenetic Regulation of Dental Pulp Stem Cell Fate |
title_short | Epigenetic Regulation of Dental Pulp Stem Cell Fate |
title_sort | epigenetic regulation of dental pulp stem cell fate |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603635/ https://www.ncbi.nlm.nih.gov/pubmed/33149742 http://dx.doi.org/10.1155/2020/8876265 |
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