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Epigenetic Regulation of Dental Pulp Stem Cell Fate

Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipot...

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Detalles Bibliográficos
Autores principales: Zhou, Dan, Gan, Lu, Peng, Yiran, Zhou, Yachuan, Zhou, Xin, Wan, Mian, Fan, Yi, Xu, Xin, Zhou, Xuedong, Zheng, Liwei, Du, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603635/
https://www.ncbi.nlm.nih.gov/pubmed/33149742
http://dx.doi.org/10.1155/2020/8876265
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author Zhou, Dan
Gan, Lu
Peng, Yiran
Zhou, Yachuan
Zhou, Xin
Wan, Mian
Fan, Yi
Xu, Xin
Zhou, Xuedong
Zheng, Liwei
Du, Wei
author_facet Zhou, Dan
Gan, Lu
Peng, Yiran
Zhou, Yachuan
Zhou, Xin
Wan, Mian
Fan, Yi
Xu, Xin
Zhou, Xuedong
Zheng, Liwei
Du, Wei
author_sort Zhou, Dan
collection PubMed
description Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs.
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spelling pubmed-76036352020-11-03 Epigenetic Regulation of Dental Pulp Stem Cell Fate Zhou, Dan Gan, Lu Peng, Yiran Zhou, Yachuan Zhou, Xin Wan, Mian Fan, Yi Xu, Xin Zhou, Xuedong Zheng, Liwei Du, Wei Stem Cells Int Review Article Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs. Hindawi 2020-10-13 /pmc/articles/PMC7603635/ /pubmed/33149742 http://dx.doi.org/10.1155/2020/8876265 Text en Copyright © 2020 Dan Zhou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhou, Dan
Gan, Lu
Peng, Yiran
Zhou, Yachuan
Zhou, Xin
Wan, Mian
Fan, Yi
Xu, Xin
Zhou, Xuedong
Zheng, Liwei
Du, Wei
Epigenetic Regulation of Dental Pulp Stem Cell Fate
title Epigenetic Regulation of Dental Pulp Stem Cell Fate
title_full Epigenetic Regulation of Dental Pulp Stem Cell Fate
title_fullStr Epigenetic Regulation of Dental Pulp Stem Cell Fate
title_full_unstemmed Epigenetic Regulation of Dental Pulp Stem Cell Fate
title_short Epigenetic Regulation of Dental Pulp Stem Cell Fate
title_sort epigenetic regulation of dental pulp stem cell fate
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603635/
https://www.ncbi.nlm.nih.gov/pubmed/33149742
http://dx.doi.org/10.1155/2020/8876265
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