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Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study
BACKGROUND: The clinical outcomes of patients who received distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603722/ https://www.ncbi.nlm.nih.gov/pubmed/33129308 http://dx.doi.org/10.1186/s12893-020-00931-4 |
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author | Cui, Ming Liu, Jing-Kai Zheng, Bang Liu, Qiao-Fei Zhang, Lu Zhang, Li Guo, Jun-Chao Dai, Meng-Hua Zhang, Tai-Ping Liao, Quan |
author_facet | Cui, Ming Liu, Jing-Kai Zheng, Bang Liu, Qiao-Fei Zhang, Lu Zhang, Li Guo, Jun-Chao Dai, Meng-Hua Zhang, Tai-Ping Liao, Quan |
author_sort | Cui, Ming |
collection | PubMed |
description | BACKGROUND: The clinical outcomes of patients who received distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood. METHODS: Information from patients undergoing distal pancreatectomy (DP) between January 2014 and June 2019 at a single institution was reviewed. A linear mixed-effects model was used to compare dynamic hematological changes between different groups. RESULTS: A total of 302 patients who underwent DP were enrolled. In the long term, most postoperative hematological parameters remained significantly higher than preoperative levels in the DPS group, while postoperative lymphocyte, monocyte, basophil, and platelet levels returned to preoperative levels in the SPDP group. All postoperative hematological parameters except for red blood cell count and serum hemoglobulin level were significantly higher in the DPS group than in the SPDP group. There were no significant differences in hematological changes between the splenic vessel preservation (SVP) and Warshaw technique (WT) groups. CONCLUSIONS: Postoperative hematological changes were significantly different between the DPS and SPDP groups. Compared to DPS, SPDP reduced abnormal hematological changes caused by splenectomy. SVP and WT were comparable in terms of postoperative hematological changes. |
format | Online Article Text |
id | pubmed-7603722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76037222020-11-02 Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study Cui, Ming Liu, Jing-Kai Zheng, Bang Liu, Qiao-Fei Zhang, Lu Zhang, Li Guo, Jun-Chao Dai, Meng-Hua Zhang, Tai-Ping Liao, Quan BMC Surg Research Article BACKGROUND: The clinical outcomes of patients who received distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood. METHODS: Information from patients undergoing distal pancreatectomy (DP) between January 2014 and June 2019 at a single institution was reviewed. A linear mixed-effects model was used to compare dynamic hematological changes between different groups. RESULTS: A total of 302 patients who underwent DP were enrolled. In the long term, most postoperative hematological parameters remained significantly higher than preoperative levels in the DPS group, while postoperative lymphocyte, monocyte, basophil, and platelet levels returned to preoperative levels in the SPDP group. All postoperative hematological parameters except for red blood cell count and serum hemoglobulin level were significantly higher in the DPS group than in the SPDP group. There were no significant differences in hematological changes between the splenic vessel preservation (SVP) and Warshaw technique (WT) groups. CONCLUSIONS: Postoperative hematological changes were significantly different between the DPS and SPDP groups. Compared to DPS, SPDP reduced abnormal hematological changes caused by splenectomy. SVP and WT were comparable in terms of postoperative hematological changes. BioMed Central 2020-10-31 /pmc/articles/PMC7603722/ /pubmed/33129308 http://dx.doi.org/10.1186/s12893-020-00931-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Cui, Ming Liu, Jing-Kai Zheng, Bang Liu, Qiao-Fei Zhang, Lu Zhang, Li Guo, Jun-Chao Dai, Meng-Hua Zhang, Tai-Ping Liao, Quan Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study |
title | Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study |
title_full | Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study |
title_fullStr | Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study |
title_full_unstemmed | Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study |
title_short | Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study |
title_sort | dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603722/ https://www.ncbi.nlm.nih.gov/pubmed/33129308 http://dx.doi.org/10.1186/s12893-020-00931-4 |
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