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Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma
The tumor microenvironment (TME) is a complex multicellular functional compartment that includes fibroblasts, myofibroblasts, endothelial cells, immune cells, and extracellular matrix (ECM) elements. The microenvironment provides an optimum condition for the initiation, growth, and dissemination of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603733/ https://www.ncbi.nlm.nih.gov/pubmed/33292459 http://dx.doi.org/10.1186/s13578-020-00488-y |
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author | Zhang, Jie Gu, Chaoyu Song, Qianqian Zhu, Mengqi Xu, Yuqing Xiao, Mingbing Zheng, Wenjie |
author_facet | Zhang, Jie Gu, Chaoyu Song, Qianqian Zhu, Mengqi Xu, Yuqing Xiao, Mingbing Zheng, Wenjie |
author_sort | Zhang, Jie |
collection | PubMed |
description | The tumor microenvironment (TME) is a complex multicellular functional compartment that includes fibroblasts, myofibroblasts, endothelial cells, immune cells, and extracellular matrix (ECM) elements. The microenvironment provides an optimum condition for the initiation, growth, and dissemination of hepatocellular carcinoma (HCC). As one of the critical and abundant components in tumor microenvironment, cancer-associated fibroblasts (CAFs) have been implicated in the progression of HCC. Through secreting various growth factors and cytokines, CAFs contribute to the ECM remodeling, stem features, angiogenesis, immunosuppression, and vasculogenic mimicry (VM), which reinforce the initiation and development of HCC. In order to restrain the CAFs-initiated HCC progression, current strategies include targeting specific markers, engineering CAFs with tumor-suppressive phenotype, depleting CAFs’ precursors, and repressing the secretions or downstream signaling. In this review, we update the emerging understanding of CAFs in HCC, with particular emphasis on cellular origin, phenotypes, biological functions and targeted strategies. It provides insights into the targeting CAFs for HCC treatment. |
format | Online Article Text |
id | pubmed-7603733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76037332020-11-02 Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma Zhang, Jie Gu, Chaoyu Song, Qianqian Zhu, Mengqi Xu, Yuqing Xiao, Mingbing Zheng, Wenjie Cell Biosci Review The tumor microenvironment (TME) is a complex multicellular functional compartment that includes fibroblasts, myofibroblasts, endothelial cells, immune cells, and extracellular matrix (ECM) elements. The microenvironment provides an optimum condition for the initiation, growth, and dissemination of hepatocellular carcinoma (HCC). As one of the critical and abundant components in tumor microenvironment, cancer-associated fibroblasts (CAFs) have been implicated in the progression of HCC. Through secreting various growth factors and cytokines, CAFs contribute to the ECM remodeling, stem features, angiogenesis, immunosuppression, and vasculogenic mimicry (VM), which reinforce the initiation and development of HCC. In order to restrain the CAFs-initiated HCC progression, current strategies include targeting specific markers, engineering CAFs with tumor-suppressive phenotype, depleting CAFs’ precursors, and repressing the secretions or downstream signaling. In this review, we update the emerging understanding of CAFs in HCC, with particular emphasis on cellular origin, phenotypes, biological functions and targeted strategies. It provides insights into the targeting CAFs for HCC treatment. BioMed Central 2020-10-31 /pmc/articles/PMC7603733/ /pubmed/33292459 http://dx.doi.org/10.1186/s13578-020-00488-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Zhang, Jie Gu, Chaoyu Song, Qianqian Zhu, Mengqi Xu, Yuqing Xiao, Mingbing Zheng, Wenjie Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma |
title | Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma |
title_full | Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma |
title_fullStr | Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma |
title_full_unstemmed | Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma |
title_short | Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma |
title_sort | identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603733/ https://www.ncbi.nlm.nih.gov/pubmed/33292459 http://dx.doi.org/10.1186/s13578-020-00488-y |
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