Post-translational modifications of PRC2: signals directing its activity

Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex maintains gene transcriptional repression and plays an essential role in the maintenance of cellular identity as well as normal organismal devel...

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Detalles Bibliográficos
Autores principales: Yang, Yiqi, Li, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603765/
https://www.ncbi.nlm.nih.gov/pubmed/33129354
http://dx.doi.org/10.1186/s13072-020-00369-1
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author Yang, Yiqi
Li, Gang
author_facet Yang, Yiqi
Li, Gang
author_sort Yang, Yiqi
collection PubMed
description Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex maintains gene transcriptional repression and plays an essential role in the maintenance of cellular identity as well as normal organismal development. The activity of PRC2, including its genomic targeting and catalytic activity, is controlled by various signals. Recent studies have revealed that these signals involve cis chromatin features, PRC2 facultative subunits and post-translational modifications (PTMs) of PRC2 subunits. Overall, these findings have provided insight into the biochemical signals directing PRC2 function, although many mysteries remain.
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spelling pubmed-76037652020-11-02 Post-translational modifications of PRC2: signals directing its activity Yang, Yiqi Li, Gang Epigenetics Chromatin Review Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex maintains gene transcriptional repression and plays an essential role in the maintenance of cellular identity as well as normal organismal development. The activity of PRC2, including its genomic targeting and catalytic activity, is controlled by various signals. Recent studies have revealed that these signals involve cis chromatin features, PRC2 facultative subunits and post-translational modifications (PTMs) of PRC2 subunits. Overall, these findings have provided insight into the biochemical signals directing PRC2 function, although many mysteries remain. BioMed Central 2020-10-31 /pmc/articles/PMC7603765/ /pubmed/33129354 http://dx.doi.org/10.1186/s13072-020-00369-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yang, Yiqi
Li, Gang
Post-translational modifications of PRC2: signals directing its activity
title Post-translational modifications of PRC2: signals directing its activity
title_full Post-translational modifications of PRC2: signals directing its activity
title_fullStr Post-translational modifications of PRC2: signals directing its activity
title_full_unstemmed Post-translational modifications of PRC2: signals directing its activity
title_short Post-translational modifications of PRC2: signals directing its activity
title_sort post-translational modifications of prc2: signals directing its activity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603765/
https://www.ncbi.nlm.nih.gov/pubmed/33129354
http://dx.doi.org/10.1186/s13072-020-00369-1
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