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Effects of β-carotene intake on the risk of fracture: a Bayesian meta-analysis
BACKGROUND: Epidemiological studies examining the association between β-carotene intake and risk of fracture have reported inconsistent findings. We conducted a meta-analysis to investigate the association between β-carotene intake and risk of fracture. METHODS: We systematically searched PubMed, EM...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603770/ https://www.ncbi.nlm.nih.gov/pubmed/33129293 http://dx.doi.org/10.1186/s12891-020-03733-0 |
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author | Charkos, Tesfaye Getachew Liu, Yawen Oumer, Kemal Sherefa Vuong, Ann M. Yang, Shuman |
author_facet | Charkos, Tesfaye Getachew Liu, Yawen Oumer, Kemal Sherefa Vuong, Ann M. Yang, Shuman |
author_sort | Charkos, Tesfaye Getachew |
collection | PubMed |
description | BACKGROUND: Epidemiological studies examining the association between β-carotene intake and risk of fracture have reported inconsistent findings. We conducted a meta-analysis to investigate the association between β-carotene intake and risk of fracture. METHODS: We systematically searched PubMed, EMBASE and Cochrane library databases for relevant articles that were published until December 2019. We also identified studies from reference lists of articles identified from the clinical databases. The frequentist and Bayesian random-effects model was used to synthesize data. RESULTS: Nine studies with a total of 190,545 men and women, with an average age of 59.8 years, were included in this meta-analysis. For β-carotene intake (1.76–14.30 mg/day), the pooled risk ratio (RR) of any fracture was 0.67 (95% Credible Interval (CrI): 0.51–0.82; heterogeneity: P = 0.66, I(2) = 0.00%) and 0.63 (95%CrI: 0.44–0. 82) for hip fracture. By study design, the pooled RRs were 0.55 (95% CrI: 0.14–0.96) for case-control studies and 0.82 (95% CrI: 0.58–0.99) for cohort studies. By geographic region, the pooled RRs were 0.58 (95% CrI: 0.28–0.89), 0.86 (95% CrI: 0.35–0.1.37), and 0.91(95% CrI: 0.75–1.00) for studies conducted in China, the United States, and Europe, respectively. By sex, the pooled RRs were 0.88 (95% CrI: 0.73–0.99) for males and 0.76 (95% CrI, 0.44–1.07) for females. There was a 95% probability that β-carotene intake reduces risk of hip fracture and any type of fracture by more than 20%. CONCLUSIONS: The present meta-analysis suggests that β-carotene intake was inversely associated with fracture risk, which was consistently observed for case-control and cohort studies. Randomized controlled trials are warranted to confirm this relationship. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-020-03733-0. |
format | Online Article Text |
id | pubmed-7603770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76037702020-11-02 Effects of β-carotene intake on the risk of fracture: a Bayesian meta-analysis Charkos, Tesfaye Getachew Liu, Yawen Oumer, Kemal Sherefa Vuong, Ann M. Yang, Shuman BMC Musculoskelet Disord Research Article BACKGROUND: Epidemiological studies examining the association between β-carotene intake and risk of fracture have reported inconsistent findings. We conducted a meta-analysis to investigate the association between β-carotene intake and risk of fracture. METHODS: We systematically searched PubMed, EMBASE and Cochrane library databases for relevant articles that were published until December 2019. We also identified studies from reference lists of articles identified from the clinical databases. The frequentist and Bayesian random-effects model was used to synthesize data. RESULTS: Nine studies with a total of 190,545 men and women, with an average age of 59.8 years, were included in this meta-analysis. For β-carotene intake (1.76–14.30 mg/day), the pooled risk ratio (RR) of any fracture was 0.67 (95% Credible Interval (CrI): 0.51–0.82; heterogeneity: P = 0.66, I(2) = 0.00%) and 0.63 (95%CrI: 0.44–0. 82) for hip fracture. By study design, the pooled RRs were 0.55 (95% CrI: 0.14–0.96) for case-control studies and 0.82 (95% CrI: 0.58–0.99) for cohort studies. By geographic region, the pooled RRs were 0.58 (95% CrI: 0.28–0.89), 0.86 (95% CrI: 0.35–0.1.37), and 0.91(95% CrI: 0.75–1.00) for studies conducted in China, the United States, and Europe, respectively. By sex, the pooled RRs were 0.88 (95% CrI: 0.73–0.99) for males and 0.76 (95% CrI, 0.44–1.07) for females. There was a 95% probability that β-carotene intake reduces risk of hip fracture and any type of fracture by more than 20%. CONCLUSIONS: The present meta-analysis suggests that β-carotene intake was inversely associated with fracture risk, which was consistently observed for case-control and cohort studies. Randomized controlled trials are warranted to confirm this relationship. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-020-03733-0. BioMed Central 2020-10-31 /pmc/articles/PMC7603770/ /pubmed/33129293 http://dx.doi.org/10.1186/s12891-020-03733-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Charkos, Tesfaye Getachew Liu, Yawen Oumer, Kemal Sherefa Vuong, Ann M. Yang, Shuman Effects of β-carotene intake on the risk of fracture: a Bayesian meta-analysis |
title | Effects of β-carotene intake on the risk of fracture: a Bayesian meta-analysis |
title_full | Effects of β-carotene intake on the risk of fracture: a Bayesian meta-analysis |
title_fullStr | Effects of β-carotene intake on the risk of fracture: a Bayesian meta-analysis |
title_full_unstemmed | Effects of β-carotene intake on the risk of fracture: a Bayesian meta-analysis |
title_short | Effects of β-carotene intake on the risk of fracture: a Bayesian meta-analysis |
title_sort | effects of β-carotene intake on the risk of fracture: a bayesian meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603770/ https://www.ncbi.nlm.nih.gov/pubmed/33129293 http://dx.doi.org/10.1186/s12891-020-03733-0 |
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