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Organoid based personalized medicine: from bench to bedside
Three-dimensional cultured organoids have become a powerful in vitro research tool that preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be established from both pluripotent stem cells and adult stem cells. Organoids derived from adult stem cells can be established dir...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603915/ https://www.ncbi.nlm.nih.gov/pubmed/33135109 http://dx.doi.org/10.1186/s13619-020-00059-z |
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author | Li, Yaqi Tang, Peiyuan Cai, Sanjun Peng, Junjie Hua, Guoqiang |
author_facet | Li, Yaqi Tang, Peiyuan Cai, Sanjun Peng, Junjie Hua, Guoqiang |
author_sort | Li, Yaqi |
collection | PubMed |
description | Three-dimensional cultured organoids have become a powerful in vitro research tool that preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be established from both pluripotent stem cells and adult stem cells. Organoids derived from adult stem cells can be established directly from diseased epithelium and matched normal tissues, and organoids can also be genetically manipulated by CRISPR-Cas9 technology. Applications of organoids in basic research involve the modeling of human development and diseases, including genetic, infectious and malignant diseases. Importantly, accumulating evidence suggests that biobanks of patient-derived organoids for many cancers and cystic fibrosis have great value for drug development and personalized medicine. In addition, organoids hold promise for regenerative medicine. In the present review, we discuss the applications of organoids in the basic and translational research. |
format | Online Article Text |
id | pubmed-7603915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-76039152020-11-02 Organoid based personalized medicine: from bench to bedside Li, Yaqi Tang, Peiyuan Cai, Sanjun Peng, Junjie Hua, Guoqiang Cell Regen Review Three-dimensional cultured organoids have become a powerful in vitro research tool that preserves genetic, phenotypic and behavioral trait of in vivo organs, which can be established from both pluripotent stem cells and adult stem cells. Organoids derived from adult stem cells can be established directly from diseased epithelium and matched normal tissues, and organoids can also be genetically manipulated by CRISPR-Cas9 technology. Applications of organoids in basic research involve the modeling of human development and diseases, including genetic, infectious and malignant diseases. Importantly, accumulating evidence suggests that biobanks of patient-derived organoids for many cancers and cystic fibrosis have great value for drug development and personalized medicine. In addition, organoids hold promise for regenerative medicine. In the present review, we discuss the applications of organoids in the basic and translational research. Springer Singapore 2020-11-02 /pmc/articles/PMC7603915/ /pubmed/33135109 http://dx.doi.org/10.1186/s13619-020-00059-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Li, Yaqi Tang, Peiyuan Cai, Sanjun Peng, Junjie Hua, Guoqiang Organoid based personalized medicine: from bench to bedside |
title | Organoid based personalized medicine: from bench to bedside |
title_full | Organoid based personalized medicine: from bench to bedside |
title_fullStr | Organoid based personalized medicine: from bench to bedside |
title_full_unstemmed | Organoid based personalized medicine: from bench to bedside |
title_short | Organoid based personalized medicine: from bench to bedside |
title_sort | organoid based personalized medicine: from bench to bedside |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603915/ https://www.ncbi.nlm.nih.gov/pubmed/33135109 http://dx.doi.org/10.1186/s13619-020-00059-z |
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