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Intrinsically Magnetic Cells: A Review on Their Natural Occurrence and Synthetic Generation
The magnetization of non-magnetic cells has great potential to aid various processes in medicine, but also in bioprocess engineering. Current approaches to magnetize cells with magnetic nanoparticles (MNPs) require cellular uptake or adsorption through in vitro manipulation of cells. A relatively ne...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604359/ https://www.ncbi.nlm.nih.gov/pubmed/33195134 http://dx.doi.org/10.3389/fbioe.2020.573183 |
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author | Pekarsky, Alexander Spadiut, Oliver |
author_facet | Pekarsky, Alexander Spadiut, Oliver |
author_sort | Pekarsky, Alexander |
collection | PubMed |
description | The magnetization of non-magnetic cells has great potential to aid various processes in medicine, but also in bioprocess engineering. Current approaches to magnetize cells with magnetic nanoparticles (MNPs) require cellular uptake or adsorption through in vitro manipulation of cells. A relatively new field of research is “magnetogenetics” which focuses on in vivo production and accumulation of magnetic material. Natural intrinsically magnetic cells (IMCs) produce intracellular, MNPs, and are called magnetotactic bacteria (MTB). In recent years, researchers have unraveled function and structure of numerous proteins from MTB. Furthermore, protein engineering studies on such MTB proteins and other potentially magnetic proteins, like ferritins, highlight that in vivo magnetization of non-magnetic hosts is a thriving field of research. This review summarizes current knowledge on recombinant IMC generation and highlights future steps that can be taken to succeed in transforming non-magnetic cells to IMCs. |
format | Online Article Text |
id | pubmed-7604359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76043592020-11-13 Intrinsically Magnetic Cells: A Review on Their Natural Occurrence and Synthetic Generation Pekarsky, Alexander Spadiut, Oliver Front Bioeng Biotechnol Bioengineering and Biotechnology The magnetization of non-magnetic cells has great potential to aid various processes in medicine, but also in bioprocess engineering. Current approaches to magnetize cells with magnetic nanoparticles (MNPs) require cellular uptake or adsorption through in vitro manipulation of cells. A relatively new field of research is “magnetogenetics” which focuses on in vivo production and accumulation of magnetic material. Natural intrinsically magnetic cells (IMCs) produce intracellular, MNPs, and are called magnetotactic bacteria (MTB). In recent years, researchers have unraveled function and structure of numerous proteins from MTB. Furthermore, protein engineering studies on such MTB proteins and other potentially magnetic proteins, like ferritins, highlight that in vivo magnetization of non-magnetic hosts is a thriving field of research. This review summarizes current knowledge on recombinant IMC generation and highlights future steps that can be taken to succeed in transforming non-magnetic cells to IMCs. Frontiers Media S.A. 2020-10-19 /pmc/articles/PMC7604359/ /pubmed/33195134 http://dx.doi.org/10.3389/fbioe.2020.573183 Text en Copyright © 2020 Pekarsky and Spadiut. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Pekarsky, Alexander Spadiut, Oliver Intrinsically Magnetic Cells: A Review on Their Natural Occurrence and Synthetic Generation |
title | Intrinsically Magnetic Cells: A Review on Their Natural Occurrence and Synthetic Generation |
title_full | Intrinsically Magnetic Cells: A Review on Their Natural Occurrence and Synthetic Generation |
title_fullStr | Intrinsically Magnetic Cells: A Review on Their Natural Occurrence and Synthetic Generation |
title_full_unstemmed | Intrinsically Magnetic Cells: A Review on Their Natural Occurrence and Synthetic Generation |
title_short | Intrinsically Magnetic Cells: A Review on Their Natural Occurrence and Synthetic Generation |
title_sort | intrinsically magnetic cells: a review on their natural occurrence and synthetic generation |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604359/ https://www.ncbi.nlm.nih.gov/pubmed/33195134 http://dx.doi.org/10.3389/fbioe.2020.573183 |
work_keys_str_mv | AT pekarskyalexander intrinsicallymagneticcellsareviewontheirnaturaloccurrenceandsyntheticgeneration AT spadiutoliver intrinsicallymagneticcellsareviewontheirnaturaloccurrenceandsyntheticgeneration |