Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10

Viruses employ multiple strategies to inhibit host mRNA nuclear export. Distinct to the generally nonselective inhibition mechanisms, ORF10 from gammaherpesviruses inhibits mRNA export in a transcript-selective manner by interacting with Rae1 (RNA export 1) and Nup98 (nucleoporin 98). We now report...

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Detalles Bibliográficos
Autores principales: Feng, Han, Tian, Huabin, Wang, Yong, Zhang, Qixiang, Lin, Ni, Liu, Songqing, Yu, Yang, Deng, Hongyu, Gao, Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604486/
https://www.ncbi.nlm.nih.gov/pubmed/33033226
http://dx.doi.org/10.1073/pnas.2007774117

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