Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity

Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5 million cases of severe illness and ∼290,000 to 645,000 deaths annually worldwide. The molecular mechanisms underlying these disparate outcomes are currently unknown. Glycosylation within the human host plays a...

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Detalles Bibliográficos
Autores principales: Heindel, Daniel W., Koppolu, Sujeethraj, Zhang, Yue, Kasper, Brian, Meche, Lawrence, Vaiana, Christopher A., Bissel, Stephanie J., Carter, Chalise E., Kelvin, Alyson A., Elaish, Mohamed, Lopez-Orozco, Joaquin, Zhang, Bin, Zhou, Bin, Chou, Tsui-Wen, Lashua, Lauren, Hobman, Tom C., Ross, Ted M., Ghedin, Elodie, Mahal, Lara K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604487/
https://www.ncbi.nlm.nih.gov/pubmed/33046650
http://dx.doi.org/10.1073/pnas.2008203117

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