Cyclic peptides can engage a single binding pocket through highly divergent modes

Cyclic peptide library screening technologies show immense promise for identifying drug leads and chemical probes for challenging targets. However, the structural and functional diversity encoded within such libraries is largely undefined. We have systematically profiled the affinity, selectivity, a...

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Detalles Bibliográficos
Autores principales: Patel, Karishma, Walport, Louise J., Walshe, James L., Solomon, Paul D., Low, Jason K. K., Tran, Daniel H., Mouradian, Kevork S., Silva, Ana P. G., Wilkinson-White, Lorna, Norman, Alexander, Franck, Charlotte, Matthews, Jacqueline M., Guss, J. Mitchell, Payne, Richard J., Passioura, Toby, Suga, Hiroaki, Mackay, Joel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604503/
https://www.ncbi.nlm.nih.gov/pubmed/33046654
http://dx.doi.org/10.1073/pnas.2003086117

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